Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases  

作　　者：Wenyan Xu Liling Li Liangcheng Du Ninghua Tan 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences,Kunming 650204, China [2]Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA [3]Graduate University of Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Acta Biochimica et Biophysica Sinica》2011年第10期757-762,共6页生物化学与生物物理学报（英文版）

摘　　要：An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.

关 键 词：ribosomal peptide CYCLOPEPTIDES nonribosomal peptide synthetase cyclization mechanism 

分 类 号：Q522[生物学—生物化学] Q55