血清乳酸脱氢酶及β_2-微球蛋白联合C反应蛋白检测在诊断急性髓细胞白血病中价值  

Combined detection of lactate dehydrogenase,β_2-microglobulin and C-reactive protein in the diagnosis of acute myelogenous leukemia

作　　者：孔荣[1] 邱宏春 吴鹏飞[1] 王勇[1] 吴得红 刘倩[1] 

机构地区：[1]昆山市第三人民医院血液科,江苏省215300

出　　处：《中华实用诊断与治疗杂志》2011年第11期1061-1062,1066,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：昆山科技发展计划项目(SYSD2010062)

摘　　要：目的探讨急性髓细胞白血病患者在初发、缓解、复发时血清乳酸脱氢酶(lactate dehydrogenase,LDH)、β2-微球蛋白(β2-microglobulin,β2-MG)及C反应蛋白(C-reactive protein,CRP)水平的变化及临床意义。方法检测100例急性髓细胞白血病患者血清LDH,β2-MG及CRP水平并进行比较,分析其与治疗效果及预后的关系,并与40例健康体检者(对照组)进行比较。结果急性髓细胞白血病患者血清LDH,β2-MG及CRP水平在初发组、复发组高于对照组和缓解组(P<0.01);缓解组与对照组比较差异无统计学意义(P>0.05)。结论联合检测LDH,β2-MG及CRP水平对于判断急性髓细胞白血病治疗效果、预后及复发有一定价值。Objective To research the changes and clinical significance of lactate dehydrogenase, β2-microglobulin and C-reactive protein in the stages of newly diagnosis, remission and progression of acute myelogenous leukemia. Methods The levels of lactate dehydrogenase, β2-microglobulin and C reactive protein were detected and compared in 100 cases of acute myelogenous leukemia to analyze the relationship between the curative effect and prognosis, and were compared with other 40 healthy controls（control group）. Results The levels of lactate dehydrogenase, β2-mieroglobulin and C reactive protein were higher in the newly diagnosis stage and progression stage of acute myelogenous leukemia than those in remission stage and control group（P〈0.01）, and there were no significant differences between remission stage and control group（P〉0.05）. Conclusion The combined detection of levels of lactate dehyclrogenase, β2-microglobulin and C-reactive protein has some value to predicting curative effect, prognosis and recurrence of acute myelogenous leukemia.

关 键 词：急性髓细胞白血病 乳酸脱氢酶 Β2-微球蛋白 C反应蛋白 

分 类 号：R733.71[医药卫生—肿瘤]