Propofol vs traditional sedative agents for endoscopic retrograde cholangiopancreatography:A meta-analysis  

作　　者：Lu-Long Bo Yu Bai Jin-Jun Bian Ping-Shan Wen Jin-Bao Li Xiao-Ming Deng 

机构地区：[1]Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, 200433 Shanghai, China [2]Evidence-Based Medicine Group, Department of Gastro-enterology, Changhai Hospital, Second Military Medical University, 200433 Shanghai, China

出　　处：《World Journal of Gastroenterology》2011年第30期3538-3543,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by The grants from the Department of Anesthesiology and Intensive Care of Changhai Hospital,Shanghai,China

摘　　要：AIM:To investigate the efficacy and safety of propofol sedation for endoscopic retrograde cholangiopancreatography(ERCP).METHODS:Databases including PubMed,Embase,and the Cochrane Central Register of Controlled Trials updated as of October 2010 were searched.Main outcome measures were ERCP procedure duration,recovery time,incidence of hypotension and hypoxia.RESULTS:Six trials with a total of 663 patients were included.The pooled mean difference in ERCP procedure duration between the propofol and traditional sedative agents was-8.05(95%CI:-16.74 to 0.63),with no significant difference between the groups.Thepooled mean difference in the recovery time was-18.69(95%CI:-25.44 to-11.93),which showed a significant reduction with use of propofol sedation.Compared with traditional sedative agents,the pooled OR with propofol sedation for ERCP causing hypotension or hypoxia was 1.69(95%CI:0.82-3.50)and 0.90(95%CI:0.55-1.49),respectively,which indicated no significant difference between the groups.CONCLUSION:Propofol sedation during ERCP leads to shorter recovery time without an increase of cardiopulmonary side effects.Propofol sedation can provide adequate sedation during ERCP.AIM： To investigate the efficacy and safety of propofol sedation for endoscopic retrograde cholangiopancreatography （ERCP）. METHODS： Databases including PubMed, Embase, and the Cochrane Central Register of Controlled Trials updated as of October 2010 were searched. Main outcome measures were ERCP procedure duration, recovery time, incidence of hypotension and hypoxia. RESULTS： Six trials with a total of 663 patients were included. The pooled mean difference in ERCP procedure duration between the propofol and traditional sedative agents was -8.05 （95% CI： -16.74 to 0.63）, with no significant difference between the groups. The pooled mean difference in the recovery time was -18.69 （95% CI： -25.44 to -11.93）, which showed a significant reduction with use of propofol sedation. Compared with traditional sedative agents, the pooled OR with propofol sedation for ERCP causing hypotension or hypoxia was 1.69 （95% CI： 0.82-3.50） and 0.90 （95% CI： 0.55-1.49）, respectively, which indicated no significant difference between the groups. CONCLUSION： Propofol sedation during ERCP leads to shorter recovery time without an increase of cardiopulmonary side effects. Propofol sedation can provide adequate sedation during ERCP.

关 键 词：Endoscopic retrograde cholangiopancrea-tography PROPOFOL Sedative agents META-ANALYSIS Outcomes 

分 类 号：S859.791[农业科学—临床兽医学] TQ460.72[农业科学—兽医学]