联合增强MR与DWI评估星形细胞瘤生物学特性的应用研究  

Application study of combining CE-MR with DWI in evaluating the biological behavior of astrocytoma

作　　者：王锡臻[1] 刘芳兵[1] 赵鸿飞[1] 李莉莉[1] 李玉恩[1] 吕悦雷[1] 王少卿[1] 王滨[1] 

机构地区：[1]潍坊医学院附属医院影像中心,山东潍坊261031

出　　处：《中华肿瘤防治杂志》2011年第18期1421-1424,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(30470518);国家教育部留学回国人员启动基金项目(2005-383);山东省1020工程出学科带头人(2006-39);中青年重点科技人才(2004[卫生系统杰-15)]基金;山东省自然科学基金(ZR2009CL046);潍坊医学院大学生创新计划;潍坊医学院博士科研启动基金

摘　　要：目的:通过分析星形细胞瘤强化及DWI成像特点与临床病理指标,探讨MR评估星形细胞瘤生物学特性的价值。方法:应用GE Signa EXCITE HD 3.0T超导型磁共振扫描仪及头部八通道线圈,对67例星形细胞瘤术前进行增强MR和DWI成像检查,利用Functiontool软件对获得图像进行处理,记录肿瘤组织强化率和ADC值。根据术后HE病理图片进行细胞密度分析和WHO分级。对强化率、ADC值、细胞密度及WHO分级进行统计分析。结果:高级别星形细胞瘤强化率为(66±12)%,高于低级别星形细胞瘤强化率(36±8)%,P=0.00。高级别星形细胞瘤的ADC为(1.11±0.10)×10-3 mm2/s,低级别星形细胞瘤的ADC为(1.55±0.31)×10-3 mm2/s,P=0.00;高级别星形细胞瘤的细胞密度为(11.85±4.36)%,大于低级别星形细胞瘤的细胞密度(4.74±2.96)%,P=0.00;肿瘤的ADC值与细胞密度、WHO分级和强化率呈负相关,P值分别为0.00、0.00和0.01;肿瘤强化率与WHO分级正相关,P=0.04。结论:增强MR和DWI能从不同角度反映星形细胞瘤生物学特性,肿瘤强化率与ADC相关性从影像学角度反映出组织灌注水平与微观结构的内在关系。OBJECTIVE： To analyze the value of combining contrast-enhance MR （CE-MR） with DWI in evaluating the biological behavior of astroeytoma. METHODS： The clinic and pathologic information of 67 patients with histologically proven astrocytoma were studied. CE-MR and diffusion weighted imaging （DWI） were carried out on a GE Signa EXCITE HD 3.0T MR. All of the data was transferred to GE Advanced Workstation 4. 2. The enhancement rate and ADC values of astroeytoma were recorded. The WHO grade and cellular density of astrocytoma were aniyzed according to HE stians. The relationship among enhancement rate, ADC values WHO grades and cellular density of astrocytoma were studied. RESULTS： The enhancement rate of high-grade astrocytoma [（66± 12）%] was higher than that of low-grade astroeytoma [（36± 8） %, （P= 0.00）]. The ADC values of high-grade and low-grade astroeytoma were （1. 11 ± 0. 10） × 10^-3 mm2/s and （1.55±0. 31） × 10 s mm2/s, respectively. The ADC values of high-grade astroeytoma was lower than that of low-grade astrocytoma （P= 0.00）. The cellular density of high-grade astroeytoma [（11. 85±4. 36） %] was higher than that of low-grade astrocytoma [（4.74±2.96） %, （P=0.00）]. The ADC values were correlated negatively with WHO grade, cellular density and enhancement rate （P were 0.00, 0.00 and 0.01）. A positive correlation was observed between enhancement rate and WHO grade （P = 0. 04）. CONCLUSION： Combined utility of CE-MR and DWI can reflect the blood supply and micro-structure of astrocytoma, which is helpful to improve the evaluation of astrocytoma.

关 键 词：磁共振 扩散加权成像 生物学行为 星形细胞瘤 

分 类 号：R739.4[医药卫生—肿瘤]