Effect of secondary radiation force on aggregation between encapsulated microbubbles  

作　　者：张艳丽 郑海荣 汤孟兴 章东 

机构地区：[1]Key Laboratory of Modern Acoustics of Ministry of Education,Institute of Acoustics,Nanjing University [2]Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences [3]Department of Bioengineering,Imperial College London

出　　处：《Chinese Physics B》2011年第11期359-364,共6页中国物理B（英文版）

基　　金：supported by the National Basic Research Program of China(Grant No.2011CB707900);the National Natural Science Foundation of China(Grant Nos.10974093,11011130201,and 10904094);the Fundamental Research Funds for the Central Universities of China(Grant Nos.1103020402,1116020410,and 1112020401);the Prior Academic Program Development of Jiangsu Higher Education Institutions,China;the State key Laboratory of Acoustics of Ministry of Education,China

摘　　要：Secondary radiation force can be an attractive force causing aggregates of encapsulated microbubbles in ultrasonic molecular imaging. The influence of the secondary radiation force on aggregation between two coated bubbles is investigated in this study. Numerical calculations are performed based on four simultaneous differential equations of radial and translational motions. Results show that the secondary force can change from attraction to repulsion during approach, and stable microbubble pairs can be formed in the vicinity of resonant regions; the possibility of microbubble aggregations can be reduced by using low exciting amplitude, ultrasonic frequencies deviating from the resonant frequencies or microbubbles with small compressibility.Secondary radiation force can be an attractive force causing aggregates of encapsulated microbubbles in ultrasonic molecular imaging. The influence of the secondary radiation force on aggregation between two coated bubbles is investigated in this study. Numerical calculations are performed based on four simultaneous differential equations of radial and translational motions. Results show that the secondary force can change from attraction to repulsion during approach, and stable microbubble pairs can be formed in the vicinity of resonant regions; the possibility of microbubble aggregations can be reduced by using low exciting amplitude, ultrasonic frequencies deviating from the resonant frequencies or microbubbles with small compressibility.

关 键 词：MICROBUBBLES secondary radiation force AGGREGATION 

分 类 号：O426[理学—声学]