Preparation and evaluation of the solid dispersions of poorly soluble silybin  

难溶性药物水飞蓟宾固体分散体的制备及评价(英文)

作　　者：马燕[1] 李卫中 古锦辉[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]慧谷医药有限公司,广东广州510610

出　　处：《Journal of Chinese Pharmaceutical Sciences》2011年第6期604-608,共5页中国药学（英文版）

摘　　要：To improve its solubility and dissolution,solid dispersions of silybin in PVP K30 were prepared by the conventional solvent evaporation method and characterized by equilibrium solubility and dissolution studies,differential scanning calorimetry （DSC） and Fourier transform infrared spectroscopy（FTIR）.Silybin solid dispersions showed increased solubility and rates of dissolution compared with pure drug and corresponding physical mixtures of silybin and PVP K30.Thermograms of various solid dispersions did not show the melting peak of pure silybin,indicating that silybin was in amorphous form inside the polymer carrier.FTIR studies demonstrated the presence of interactions between hydroxyl groups of silybin and carbonyl groups of PVP K30 in solid dispersions.Solid dispersion techniques can be used to formulate water insoluble drugs to improve their dissolution in vitro and absorption in vivo.采用溶剂法制备水飞蓟宾的PVP K30固体分散体以提高其溶解度和溶出速率;通过平衡溶解度、溶出速率、DSC和FTIR等方法验证和定性分析制备的固体分散体。水飞蓟宾的固体分散体与原料药及物理混合物相比,改善了药物的溶解度和溶出速率。DSC曲线显示水飞蓟宾的吸热峰消失,表明水飞蓟宾以无定形物分散于载体材料中;FTIR的研究结果表明水飞蓟宾的羟基和PVP K30的羰基发生了反应。固体分散技术可应用于难溶性药物以改善其体外溶出及进一步的体内吸收。

关 键 词：SILYBIN Solid dispersions PVP K30 DSC FTIR 

分 类 号：R944[医药卫生—药剂学]