SILYBIN

作品数：23被引量：112H指数：6
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相关领域：医药卫生化学工程更多>>
相关作者：周艳霞刘艳李馨儒梅康康胡容峰更多>>
相关机构：中国药科大学北京大学安徽中医学院广州中医药大学更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Silybin regulates P450s activity by attenuating endoplasmic reticulum stress in mouse nonalcoholic fatty liver disease被引量：2
《Acta Pharmacologica Sinica》2023年第1期133-144,共12页Jing Wu Yun-ge Lou Xu-le Yang Rui Wang Ran Zhang Ji-ye Aa Guang-ji Wang Yuan Xie 
This project was supported by the National Natural Science Foundation of China (No.81872932,81673679);the Six Talent Peaks Project in Jiangsu Province (SWYY-061);the Sanming Project of Medicine in Shenzhen (SZSM201801060);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University (No.SKLNMZZ202001).
Cytochrome P450s are important phase I metabolic enzymes located on endoplasmic reticulum(ER)involved in the metabolism of endogenous and exogenous substances.Our previous study showed that a hepatoprotective agent si...
关键词：Non-alcoholic fatty liver disease SILYBIN P450s ER stress cyt b5 cyt c 
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptorα被引量：5
《Chinese Journal of Natural Medicines》2021年第6期401-411,共11页CUI Shuang PAN Xiao-Jie GE Chao-Liang GUO Yi-Tong ZHANG Peng-Fei YAN Ting-Ting ZHOU Ji-Yu HE Qing-Xian CHENG Long-Hao WANG Guang-Ji HAO Hai-Ping WANG Hong 
supported by the National Natural Science Foundation of China(Nos.81720108032,81930109,82073926,82073928);the Project for Major New Drug Innovation and Development(Nos.2018ZX09711001-002-003,2018ZX09711002-001-004);Overseas Expertise Introduction Project for Discipline Innovation(No.G20582017001).
Nonalcoholic fatty liver disease(NAFLD)is regarded as the most common liver disease with no approved therapeutic drug currently.Silymarin,an extract from the seeds of Silybum marianum,has been used for centuries for t...
关键词：SILYBIN NAFLD PPARa Lipid metabolism FENOFIBRATE 
Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus–PVPVA complex被引量：5
《Acta Pharmaceutica Sinica B》2019年第1期107-117,共11页Chunliu Zhu Shuang Gong Jinsong Ding Miaorong Yu Ejaj Ahmad Yi Feng Yong Gan 
supported by the National Natural Science Foundation of China (grant Nos. 81573378 and 81773651);the Shanghai Science and Technology Innovation Action Plan for Basic Research, China (No. 17430741500)
Increasing the degree of supersaturation of drugs and maintaining their proper stability are very important in improving the oral bioavailability of poorly soluble drugs by a supersaturated drug delivery system(SDDS)....
关键词：SILYBIN Soluplus PVPVA COMPLEX Supersaturated DRUG delivery system ORAL BIOAVAILABILITY 
Curative effect of silybin combined with pituitrin-phentolamine for pulmonary tuberculosis complicated by acute hemoptysis
《Journal of Hainan Medical University》2017年第24期37-40,共4页Shu-Hua Li Li-Jun Zou 
Objective: To study the curative effect of silybin combined with pituitrin-phentolamine for pulmonary tuberculosis complicated by acute hemoptysis. Methods: A total of 78 patients with pulmonary tuberculosis complicat...
关键词：Pulmonary tuberculosis Cute HEMOPTYSIS SILYBIN PITUITRIN PHENTOLAMINE 
Cancer chemoprevention through dietary avonoids: what's limiting?被引量：6
《Chinese Journal of Cancer》2017年第10期455-467,共13页Haneen Amawi Charles R. Ashby Jr Amit K. Tiwari 
supported by seed-fund to AKT from Department of Pharmacology and Experimental Therapeutics at UT
Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive and cytotoxic against various cance...
关键词：FLAVONOIDS CHEMOPREVENTION SILYBIN SILYMARIN Natural product drug development PHARMACOKINETIC challenges 
Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells被引量：13
《World Journal of Gastroenterology》2016年第26期6016-6026,共11页Giulia Vecchione Elena Grasselli Adriana Voci Francesca Baldini Ignazio Grattagliano David QH Wang Piero Portincasa Laura Vergani 
Supported by MIUR-COFIN(Prot.20089SRS2X_002);Compagnia San Paolo Torino;University of Genova;and Fondazione CARIGE
AIM: To investigate in vitro the therapeutic effect and mechanisms of silybin in a cellular model of hepatic steatosis.METHODS: Rat hepatoma FaO cells were loaded with lipids by exposure to 0.75 mmol/L oleate/palmitat...
关键词：Non-alcoholic fatty liver disease Steatotic hepatocytes SILYBIN Lipid metabolism Oxidative stress Lipid droplets Mitochondrial β -OXIDATION 
A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes被引量：6
《World Journal of Gastroenterology》2013年第20期3007-3017,共11页Ignazio Grattagliano Catia V Diogo Maria Mastrodonato Ornella de Bari Michele Persichella David QH Wang Adriana Liquori Domenico Ferri Maria Rosaria Carratù Paulo J Oliveira Piero Portincasa 
Supported by Grants from MIUR(Ministero Università e Ricerca Scientifica COFIN2006);"Fondi Ateneo Ricerca Scientifica 2005/2006" from the University of Bari,Italy
AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes.METHODS:Silybin-phospholipid complex containing vitamin E(Re...
关键词：Fatty liver Glutathione Lipid PEROXIDATION NITROSOTHIOLS NITROTYROSINE THIOREDOXIN 
Simultaneous Determination of Silybin A and Silybin B in Rat Plasma and Pharmacokinetic Study
《Chinese Herbal Medicines》2011年第4期304-309,共6页CHU Yang,LI Wei,LI Zhi-wen,LI Xin-xin,MA Xiao-hui,ZHOU Shui-ping,ZHU Yong-hong Department of Pharmacology,Tianjin Tasly Institute,Tianjin 300410,China 
Objective To investigate the bioavailability and pharmacokinetics of silybin A and silybin B in rats,respectively. Methods Following iv and ig administration of silybin to 20 Wistar rats,the plasma samples were collec...
关键词：BIOAVAILABILITY LC-MS/MS PHARMACOKINETICS silybin A silybin B 
Preparation and evaluation of the solid dispersions of poorly soluble silybin
《Journal of Chinese Pharmaceutical Sciences》2011年第6期604-608,共5页马燕 李卫中 古锦辉 
To improve its solubility and dissolution,solid dispersions of silybin in PVP K30 were prepared by the conventional solvent evaporation method and characterized by equilibrium solubility and dissolution studies,differ...
关键词：SILYBIN Solid dispersions PVP K30 DSC FTIR 
Silybin and the liver: From basic research to clinical practice被引量：26
《World Journal of Gastroenterology》2011年第18期2288-2301,共14页Carmela Loguercio Davide Festi 
Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk thistle, Silymarin and silybin, are the most prescribed natural compounds, with different indications, but with no definitive re...
关键词：Milk thistle SILYMARIN Liver disease Hepatic fibrosis Hepatic inflammation Radical species 
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