Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR  

作　　者：WANG Wen-jun CAO Chen-ming JIN Chen WANG Xin WANG George-peng 

机构地区：[1]College of Pharmacy,Nankai University, Tianjin 300071, P. R. China [2]State Key Laboratory of Element-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China [3]Departments of Chemistry and Biochemistry, The Ohio State University, Columbus OH 43210, USA

出　　处：《Chemical Research in Chinese Universities》2011年第5期886-890,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos.2007CB914403, 50803029);the Natural Science Foundation of Tianjin City, China(No.10JCYBJC04100);the Fundamental Research Funds for the Central Universities of China

摘　　要：The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.

关 键 词：GLYCOCONJUGATE ANILINE CATALYSIS Kinetics Real-time NMR 

分 类 号：O482.532[理学—固体物理] TE626.9[理学—物理]