GLYCOCONJUGATE

作品数：9被引量：15H指数：2
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相关期刊：《中国体视学与图像分析》《Chemical Research in Chinese Universities》《Transactions of Tianjin University》《Chinese Journal of Chemistry》更多>>
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Supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery
《Chinese Chemical Letters》2024年第2期317-322,共6页Han Lin Yanchun Li Kun Zhou Dan Li Hangyan Yu Jie Zhao Haofei Hong Zhifang Zhou Zhimeng Wu 
supported by the National Natural Science Foundation of China(No.22177040);the Natural Science Foundation of Jiangsu Province(No.BK20200601);partly funded by the 111 Project(No.111-2-06).
Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of TACA.However,an essential requiremen...
关键词：Glycoconjugate vaccine Endogenous antibody APC-targeting Supramolecular complex sTn antigen 
Carbohydrate-based drugs launched during 2000-2021被引量：9
《Acta Pharmaceutica Sinica B》2022年第10期3783-3821,共39页Xin Cao Xiaojing Du Heng Jiao Quanlin An Ruoxue Chen Pengfei Fang Jing Wang Biao Yu 
supported by the National Natural Science Foundation of China(82173662,22031011,and 21621002);Natural Science Foundation of Shanghai(20ZR1410400,China);the Shanghai Municipal Science and Technology Major Project,the State Key Basic Research Program of the China(2018YFC0310905);the Extraordinary 2025 Elite Project of Fudan University,the Open Funding of Key Laboratory of Diagnosis and Treatment of Severe Hepato-pancreatic Diseases of Zhejiang Province(2018E10008,China);the Open Funding of State Key Laboratory of Bio-organic and Natural Products Chemistry.
Carbohydrates are fundamental molecules involved in nearly all aspects of lives,such as being involved in formating the genetic and energy materials,supporting the structure of organisms,constituting invasion and host...
关键词：Carbohydrate-based drug Glycodrug GLYCOCONJUGATE Antibiotics Antivirus drug Anticancer drug 
β-1,2-Mannan-based glycoconjugates as potential antifungal vaccines
《Chinese Chemical Letters》2022年第9期4345-4349,共5页Jun Liao Bo Pan Xiaobin Zhuo Guochao Liao Yun Gao Zhenzhen Yao Lianghua Wang Qiuye Wu Weihua Pan Binghua Jiao Qingjie Zhao 
financially supported by the Natural Science Foundation of China (Nos. 21502223, 81773580)
Phosphorylated di-,tri-and tetra-saccharides ofβ-1,2-mannan antigen derived from Candida albicans(C.albicans)cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin(KLH)and human serum alb...
关键词：β-1 2-Mannan OLIGOSACCHARIDE ANTIFUNGAL GLYCOCONJUGATE Vaccine ANTIGEN 
5-Fluorocytosine–Sugar Conjugates for Glucose Transporter-Mediated Tumor Targeting: Synthesis, Cytotoxicity, and Cellular Uptake Mechanism被引量：1
《Transactions of Tianjin University》2019年第6期611-617,共7页Yu Wang Xiaofei Cheng Hongxia Zhao Qingzhi Gao 
supported by the National Natural Science Foundation of China (No. 21772144 and No. 21801184);Tianjin Municipal Applied Basic and Key Research Scheme, China (No. 18JCQNIC06400)
Two novel sugar-conjugated 5-fluorocytosine(5-FC)antineoplastic compounds were designed and synthesized to improve the selective drug uptake by targeting the tumor-specific glucose transporter(GLUT).The antitumor acti...
关键词：WARBURG effect Glucose TRANSPORTER overexpressed 5-FLUOROCYTOSINE GLYCOCONJUGATE Tumor targeting 
Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR
《Chemical Research in Chinese Universities》2011年第5期886-890,共5页WANG Wen-jun CAO Chen-ming JIN Chen WANG Xin WANG George-peng 
Supported by the National Natural Science Foundation of China(Nos.2007CB914403, 50803029);the Natural Science Foundation of Tianjin City, China(No.10JCYBJC04100);the Fundamental Research Funds for the Central Universities of China
The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalenc...
关键词：GLYCOCONJUGATE ANILINE CATALYSIS Kinetics Real-time NMR 
Spectroscopy Investigation on Conformational Transition of Tea Glycoconjugate from Green Tea被引量：5
《Chinese Journal of Chemistry》2004年第11期1387-1390,共4页陈海霞 张民 谢笔钧 
Project supported by the National Natural Science Foundation of China (No. 30270939).
The conformational transition of a new glycoconjugate, tea glycoconjugate (TGC), was investigated by spec-troscopy techniques including circular dichroism (CD) and ultraviolet (UV) spectroscopy. The solution behaviors...
关键词：tea glycoconjugate conformational transition circular dichroism ultraviolet spectroscopy 
Synthesis of RGD-aPEG-lactoside, a Potential Anti-metastasis Glycoconjugate
《Chinese Chemical Letters》2004年第5期532-534,共3页ShuChunLI LiMinNIU HuiLI,ZhongJunLI QingLI 
The adhesive interaction between tumor cells and host cells or the extra cellular matrix plays a crucial role in metastasis. Due to the anti-metastasis effects of RGD (arginyl-glycyl -aspartic acid) and some oligosac...
关键词：RGD LACTOSE PEG anti-metastasis. 
STUDY ON GLYCOCONJUGATE CHANGES ON CELL SURFACE IN PROGRESSIVE DEVELOPMENT OF PULMONARY TUMOR
《中国体视学与图像分析》2002年第2期77-82,89,共7页WANG Xiao - mei, SHAN Jun, CHEN Zhuo - huai( Department of Pathology, Shenzhen People’s Hospital of Guangdong Province, Shenzhen 518020, China Department of Radiology, Shenzhen People s Hospital, Shenzhen 518020, China) 
Grant from the Scientific Fund of Shenzhen Science Committee (No. 299805011).
Aim: To investigate glycoconjugate changes on the cell surface of proliferative lesions and neoplasms of mice lungs at various stages of tumorigenesis, the relation between progressive development of mouse pulmonary t...
关键词：肺肿瘤 凝血素 20-甲基胆蒽 
Synthesis of a Novel Type of Glycophosphate Mimics
《Chinese Chemical Letters》2002年第4期294-295,共2页QiangXiao YongJU 等 
supports from the National Natural Science Foundation of China(No.39870415 and No.29672022);Chinese Ministry of Education and Tsinghua University.
A series of novel type of glycophosphate mimics are synthesized by Todd reaction and their structure were determined on the basis of NMR, ESI-MS.
关键词：GLYCOCONJUGATE PHOSPHATE H-PHOSPHONATE amino acids. 
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