云南高校图书馆联盟文献共享服务平台- 5-FLUOROCYTOSINE

5-FLUOROCYTOSINE: 作品数：10被引量：32H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：殷莲华姜庆张俊勇张永康王新红更多>>; 相关机构：重庆医科大学附属第二医院复旦大学耶鲁大学上海医科大学更多>>; 相关期刊：《American Journal of Analytical Chemistry》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Advances in Biological Chemistry》更多>>; 相关基金：国家自然科学基金更多>>

Simple Quantitation of Flucytosine in Low Volume Serum Samples and Evaluation of Common Endogenous Interferences by HPLC-UV: 《American Journal of Analytical Chemistry》2022年第9期289-299,共11页Abdul Rafiq Khan Ali Alothaim Waleed Tamimi Majid Alshaibani Souad Marwan Al Enazi Syed Muhammad Saad Khalid Mohammed Khan; 5-Fluorocytosine (5-FC) is used for the treatment of several infections. It is extremely important to monitor blood level concentration for maximum activity to avoid its side effects. A simple, faster, and more accura...; 关键词：5-FLUOROCYTOSINE Serum Sample HPLC-UV Method Quantification Validation

Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE被引量：2: 《Synthetic and Systems Biotechnology》2022年第3期869-877,共9页Jianping Kang Jieyi Li Zhou Guo Sijie Zhou Shuxin Su Wenhai Xiao Yi Wu Yingjin Yuan; supported by the National Key R&D Program of China(2021YFC2102500);National Natural Science Foundation of China(31971351).; Varied environmental stress can affect cell growth and activity of the cellular catalyst.Traditional path of adaptive evolution generally takes a long time to achieve a tolerance phenotype,meanwhile,it is a challenge ...; 关键词：SCRAMBLE Saccharomyces cerevisiae Structural variation GCN20 TOLERANCE

5-Fluorocytosine–Sugar Conjugates for Glucose Transporter-Mediated Tumor Targeting: Synthesis, Cytotoxicity, and Cellular Uptake Mechanism被引量：1: 《Transactions of Tianjin University》2019年第6期611-617,共7页Yu Wang Xiaofei Cheng Hongxia Zhao Qingzhi Gao; supported by the National Natural Science Foundation of China (No. 21772144 and No. 21801184);Tianjin Municipal Applied Basic and Key Research Scheme, China (No. 18JCQNIC06400); Two novel sugar-conjugated 5-fluorocytosine(5-FC)antineoplastic compounds were designed and synthesized to improve the selective drug uptake by targeting the tumor-specific glucose transporter(GLUT).The antitumor acti...; 关键词：WARBURG effect Glucose TRANSPORTER overexpressed 5-FLUOROCYTOSINE GLYCOCONJUGATE Tumor targeting

恢复connexin26表达联合载酵母菌胞嘧啶脱氨酶自杀基因纳泡杀灭膀胱癌细胞被引量：3: 《第三军医大学学报》2018年第4期322-327,共6页陈思乡姜庆张俊勇; 重庆市卫生计生委重点科研项目(2013-1-020)~~; 目的分析载双基因的阳离子纳泡联合超声靶向微泡破坏技术进行基因转染的有效性,探索恢复或上调膀胱癌细胞的缝隙连接蛋白connexin26(Cx26)表达,能否增强自杀基因系统(yeast cytosine deaminase/5-fluorocytosine,YCD/5-FC)的旁观者效应...; 关键词：缝隙连接蛋白connexin26 阳离子纳泡超声辐照自杀基因系统yeast CYTOSINE deaminase/5-fluorocytosine 膀胱癌

Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo被引量：4: 《Chinese Medical Journal》2015年第10期1384-1390,共7页Xiao-Ping Yang Ling Liu Ping Wang Sheng-Lin Ma; Background：Human sulfatase-1 （Hsulf-l） is an endosulfatase that selectively removes sulfate groups from heparan sulfate proteoglycans （HSPGs）,altering the binding of several growth factors and cytokines to HSPG t...; 关键词：Cytosine Deaminase/5-Fluorocytosine Suicide System Hepatocellular Carcinoma Human Sulfatase-1

Purification and characterization of <i>Aspergillus parasiticus</i>cytosine deaminase for possible deployment in suicide gene therapy: 《Advances in Biological Chemistry》2012年第2期152-159,共8页Hassan Zanna A. J. Nok S. Ibrahim H. M. Inuwa; Cytosine Deaminase (CD) from Aspergillus parasiticus was purified and characterized. Time course for maximal CD production (50 μmol/min/mg) was at 72 hrs. The enzyme was purified 387.73 folds with an overall yield of...; 关键词：CYTOSINE DEAMINASE CYTOSINE 5-FLUOROCYTOSINE Aspergillus PARASITICUS Activation Energy

Antitumor activity of mutant bacterial cytosine deaminase gene for colon cancer: 《World Journal of Gastroenterology》2011年第24期2958-2964,共7页Long-Ying Deng Jian-Ping Wang Zhi-Fu Gui Li-Zong Shen; AIM： To evaluate bacterial cytosine deaminase （bCD） mutant D314A and 5-fluorocytosine （5-FC） for treatment of colon cancer in a mouse model. METHODS： Recombinant lentivirus vectors that contained wild-type bCD g...; 关键词：Suicide gene therapy Bacterial cytosinedeaminase MUTANT D314A 5-FLUOROCYTOSINE Coloncancer

Antitumor effect of cytosine deaminase/5-fluorocytosine suicide gene therapy system mediated by Bifidobacterium infantis on melanoma被引量：22: 《Acta Pharmacologica Sinica》2005年第5期629-634,共6页ChengYI YingHUANG Zhi-yingGUO Shu-renWANG; Supported by CMB project(MERF-2002); Aim:To construct a Bifidobacterium infantis/CD targeting gene therapy system and observe the antitumor effect of cytosine deaminase/5-fluorocytosine(CD/5- FC)suicide gene therapy system mediated by Bifidobacterium inf...; 关键词：Bifidobacterium infantis cytosine deaminase gene therapy

In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models: 《Chinese Medical Journal》2002年第2期227-231,152-153,共5页张正望殷莲华张永康赵凤娣; OBJECTIVE: To investigate the antitumor and anti-metastatic effect of in situ transduction of adenovirus encoding cytosine deaminase (AdCD) followed by the systemic use of 5-fluorocytosine (5-FC) in the orthotopic (o....; 关键词：ADENOVIRIDAE Animals Cell Division Cytosine Deaminase Disease Models Animal FLUCYTOSINE Lymphatic Metastasis Male MICE Mice Inbred C57BL Neoplasm Transplantation Nucleoside Deaminases Prostatic Neoplasms Survival Rate Transfection Tumor Cells Cultured

Sensitization of prostate cancer cell lines to 5-fluorocytosine induced by adenoviral vector carrying a CD transcription unit: 《Chinese Medical Journal》2001年第9期76-79,109,共5页殷莲华付四清王新红 T.Nanakorn Jongho Won A.Deisserot; Objective　To investigate the efficiency of the cytosine deaminase adenoviral/5-fluorocytosine system on prostate cancer cell lines.Methods　We used cell culture, infectivity and sensitivity tests, to observe bystande...; 关键词：cytosine deaminase · 5 fluorocytosine · gene therapy · prostate cancer

5-FLUOROCYTOSINE