MUTANT

作品数：744被引量：1940H指数：19
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相关领域：医药卫生生物学更多>>
相关作者：黄巨富王耀萍吕玉兵赵颖董志刚更多>>
相关机构：中国科学院植物研究所中国科学院南京农业大学四川农业大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>
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Oncogenic activation of PIK3CA in cancers:Emerging targeted therapies in precision oncology
《Genes & Diseases》2025年第2期143-153,共11页Yuxiang Wang Valery Rozen Yiqing Zhao Zhenghe Wang 
supported by the National Institutes of Health (USA)grantsSR01CA196643,R01CA264320,R01CA260629,P50CA150964,and P30CA043703 to Zhenghe Wang.
Phosphoinositide 3-kinases(PI3Ks)are heterodimers consisting of a p110 catalytic subunit and a p85 regulatory subunit.The PlIK3CA gene,which encodes the p110a,is the most frequently mutated oncogene in cancer.Oncogeni...
关键词：Hotspot mutation Isoform/mutant-specific inhibitors Metabolism PIK3CA Tumor microenvironment 
Furmonertinib re-challenge for epidermal growth factor receptormutant lung adenocarcinoma after osimertinib-induced interstitial lung disease:A case report
《World Journal of Clinical Oncology》2025年第3期142-150,共9页Fei-Fei Wei Jing Zhang Zhe Jia Zhi-Chao Yao Chun-Qiao Chen 
Supported by Guangxi Guilin Science and Technology Fund,No.20190218-7-6.
BACKGROUND Most non-small cell lung cancer patients have epidermal growth factor receptor(EGFR)activating mutations,such as exon 19 deletion and exon 21 replacement mutations.Osimertinib is a third-generation EGFR-tyr...
关键词：Furmonertinib Osimertinib Lung adenocarcinoma Interstitial lung disease Case report 
Conferring non-strain-specific resistance to a potyvirus via overexpression of mutant potyviral coat proteins in soybean
《Journal of Integrative Plant Biology》2025年第2期202-204,共3页Sun-Jung Kwon Myung-Hwi Kim Hye Jeong Kim Phu-Tri Tran Young-Soo Chung Kook-Hyung Kim Jang-Kyun Seo 
supported by a grant from Basic Science Research Program(NRF-2022R1A2C1004728)funded by the National Research Foundation of Korea。
Dominant resistance gene(R-gene)-mediated resistance precisely targets specific pathogens,but short-term overcoming of R-gene-mediated resistance is highly possible for viral pathogens with high evolutionary capacity(...
关键词：SOYBEAN resistance DOMINANT 
Role of silent mutations in KRAS-mutant tumors
《Chinese Medical Journal》2025年第3期278-288,共11页Jun Lu Chao Zhou Feng Pan Hongyu Liu Haohua Jiang Hua Zhong Baohui Han 
National Natural Science Foundation of China(Nos.82473102,82272913,82301980,and 82072573);National Multi-disciplinary Treatment Project for Major Disease(No.2020NMDTP);Chinese Society of Clinical Oncology(Nos.Y-2019AZZD-0355 and Y-QL2019-012);Shanghai Jiao Tong University(No.YG2021QN12)
Silent mutations within the RAS gene have garnered increasing attention for their potential roles in tumorigenesis and therapeutic strategies.Kirsten-RAS(KRAS)mutations,predominantly oncogenic,are pivotal drivers in v...
关键词：MUTATIONS Silent mutation TUMOR Biological characteristics 
Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine
《World Journal of Clinical Oncology》2025年第1期25-33,共9页Jiang-Yu Bian Yu-Fang Feng Wen-Ting He Tong Zhang 
Supported by National Natural Science Foundation of China,No.82174461;Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0201-22;Technology Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A01811.
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor...
关键词：Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study 
CXCR1^(+)neutrophil infiltration orchestrates response to thirdgeneration EGFR-TKI in EGFR mutant non-small-cell lung cancer
《Signal Transduction and Targeted Therapy》2025年第1期278-292,共15页Haowei Wang Anwen Xiong Xiaoxia Chen Junhong Guo Zhuoran Tang Chunyan Wu Shengxiang Ren Caicun Zhou Jian Chen Likun Hou Tao Jiang 
supported in part by grants from the National Natural Science Foundation of China(Nos.82102859,82272875 and 12126605);Shanghai Rising-Star Program(Nos.23QA1408000 and 22QA1407800);Shanghai Science and Technology Innovation Action Plan Medical Innovation Research Program(Nos.23Y11904100 and 21Y11913600);the Health and Family Planning Commission of Shanghai Municipality(No.20224Y0067);Ningbo Top Medical and Health Research Program(No.2022030208);Shanghai Nature Foundation Project(No.21ZR1453200);National Key Clinical Specialty Construction Project,Original exploration project of Shanghai Natural Science Foundation(No.23ZR1480600);Shanghai“Rising Stars of Medical Talent”Youth Development Program Youth Medical Talents-Specialist Program.
Although third-generation Epidermal growth factor receptor—tyrosine kinase inhibitors(EGFR-TKI)is standard of care for patients with EGFR-mutant Non-small cell lung cancer(NSCLC),little is known about the predictors ...
关键词：CXCR1 TKI markedly 
Identification and characterization of a no-grain mutant(nog1)in foxtail millet
《Journal of Integrative Agriculture》2024年第12期4263-4266,共4页Hui Zhang Hui Zhi Di Yuan Hongkai Liang Wei Zhang Guanqing Jia Xianmin Diao 
supported by the National Key Research and Development Program of China(2023YFD1200704 and 2023YFD1200700);the National Natural Science Foundation of China(32241042);the China Agricultural ResearchSystem(CARS06-14.5-A04);the Key Laboratory of Crop Gene Resource and Germplasm Enhancement,Ministry of Agriculture and Rural Affairs,China,and the Technology Innovation Program of Chinese Academy of Agricultural Sciences.
Increasing crop grain yields is an urgent global priority due to population growth,shrinking arable land,and severe climate change in recent years(Tang et al.2023).Unraveling the process of panicle development is cruc...
关键词：PANICLE GRAIN branch 
Targeting TMEM16A/ANO1 inhibits the progression of BRAF mutant(V600E)melanoma through the MEK/ERK and AKT signaling pathways
《Genes & Diseases》2024年第6期5-7,共3页Meiyun Shi Jiahui Wang Xingyu Huang Linsu Liu Lutao Liu Na Zhou Xinqi Shan Huaqun Chen 
The BRAF(V600E)mutation is common in malignant melanoma patients and drives constitutive activation of the MEK/ERK signaling pathway and cancer progression.1 To date,precision therapies targeting the BRAF/MEK/ERK path...
关键词：MEK/ERK V600E BRAF 
Immunological features of EGFR-mutant non-small cell lung cancer and clinical practice:a narrative review
《Journal of the National Cancer Center》2024年第4期289-298,共10页Yi Dong Liaqat Khan Yi Yao 
supported by the Natural Science Foundation of Hubei Province of China(grant number:2022CFB114).
Immune checkpoint inhibitors(ICIs)have significantly improved outcomes for patients with advanced driver-negative non-small cell lung cancer(NSCLC).However,targeted therapy remains the preferred treatment for advanced...
关键词：Epidermal growth factor receptor(EGFR) Immunological features IMMUNOTHERAPY MUTATION Non-small cell lung cancer(NSCLC) 
Pancreatic agenesis and altered m6A methylation in the pancreas of PDX1-mutant cynomolgus macaques
《Zoological Research》2024年第6期1188-1200,共13页Wen-Hui Zhang Jiong-Han Zhuang Yun-Yi Guo Xue-Ying Chen Ya-Qing Li Jie-Qiu Xu An-Ran Zhang Bao-Yi Chen Wei Meng Yan-Hua Zhu Jun-Jiu Huang Yong-Long Guo Shi-Hua Yang 
supported by the National Key R&D Program of China(2018YFA0801404,2023YFC3403400);National Natural Science Foundation of China(81941006,32371190,32370878);Guangdong Special Support Program(2019BT02Y276,2024A1515012868);Double First-Class Discipline Promotion Project(2023B10564003);Program for Scientific Research Start-up Funds of Guangdong Ocean University(060302052408)。
As an essential transcriptional activator,PDX1 plays a crucial role in pancreatic development andβ-cell function.Mutations in the PDX1 gene may lead to type 4 maturityonset diabetes of the young(MODY4)and neonatal di...
关键词：PDX1 MODY4 Cynomolgus macaques M6A methylation modification 
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