FLUCYTOSINE

作品数:8被引量:45H指数:3
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相关领域:医药卫生更多>>
相关作者:朱兆华曾志勇文卓夫张世能黄志清更多>>
相关机构:中山医科大学孙逸仙纪念医院复旦大学交通大学更多>>
相关期刊:《Chinese Medical Journal》《Chinese Journal of Chemistry》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金:湖北省自然科学基金国家自然科学基金国家高技术研究发展计划更多>>
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Simple Quantitation of Flucytosine in Low Volume Serum Samples and Evaluation of Common Endogenous Interferences by HPLC-UV
《American Journal of Analytical Chemistry》2022年第9期289-299,共11页Abdul Rafiq Khan Ali Alothaim Waleed Tamimi Majid Alshaibani Souad Marwan Al Enazi Syed Muhammad Saad Khalid Mohammed Khan 
5-Fluorocytosine (5-FC) is used for the treatment of several infections. It is extremely important to monitor blood level concentration for maximum activity to avoid its side effects. A simple, faster, and more accura...
关键词:5-FLUOROCYTOSINE Serum Sample HPLC-UV Method Quantification Validation 
Successful Treatment with Triple Therapy of Amphotericin B, Voriconazole and Flucytosine on an AIDS Patients with Severe Cryptococcal Meningitis
《国际感染病学(电子版)》2012年第2期110-113,共4页Zhi-liang Hu Hong-xia Wei Wen-hu Yao Yong-feng Yang 
A 35-year-old man(body weight=63 kg)with AIDS complaining fever and headache after having commenced anti-retroviral therapy(ART)for a week was admitted to our hospital.Five lumbar punctures performed during38 days cou...
关键词:Cryptococcal meningitis Anti-retroviral therapy CORTICOSTEROIDS VORICONAZOLE EFAVIRENZ 
Treatment of cryptococcal meningitis with low-dose amphotericin B and flucytosine被引量:8
《Chinese Medical Journal》2012年第2期385-387,共3页Yan Dong Huang Jian-rong Lian Jiang-shan Li Lan-juan 
Background Amphotericin B (0.7 mg/kg) with flucytosine is the standard treatment for cryptococcal meningitis.However,the long treatment course can induce adverse reactions in patients; therefore,reducing the dose ma...
关键词:meningitis  cryptococcal amphotericin B  flucytosine therapeutics  cerebrospinal fluid 
Global transcriptional profiles of Trichophyton rubrum in response to Flucytosine
《Science China(Life Sciences)》2009年第12期1173-1185,共13页ZHAO Rong BIN Wen DIAO YouJiang YANG Jian LIU Tao PENG JunPing JIN Qi 
Supported by the National High Technology Research and Development Program of China (Grant No. 2006AA020504)
Trichophyton rubrum (T.rubrum) is one of the most common human fungal pathogens that cause chronic infections of the skin and nails. To identify antifungal responsive genes, cDNA microarray analysis was performed for ...
关键词:Trichophyton rubrum cDNA microarray 5-Flucytosine gene expression 
Study on Binding Reaction between Flucytosine and Bovine Serum Albumin被引量:8
《Chinese Journal of Chemistry》2005年第9期1151-1156,共6页颜承农 张华新 梅平 刘义 
Project supported by the National Natural Science Foundation of China (No. 20373051) and the National Natural Science Foundation of Hubei Province in China (No. 2005ABA067).
The binding of flucytosine to bovine serum albumin (BSA) was studied by means of fluorescence and absorption spectra under the conditions of simulant clay physiology. It showed a powerful ability to quench the fluor...
关键词:FLUCYTOSINE bovine serum albumin fluorescence spectroscopy three-dimensional fluorescence spectrum thermodynamic parameter 
Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene被引量:29
《World Journal of Gastroenterology》2002年第2期270-275,共6页Li-Zong Shen Wen-Xi Wu Qiang Ding Yi-Bing Hua,Department of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,210029,Jiangsu Province,China De-Hua Xu Zhong-Cheng Zheng Xin-Yuan Liu,Shanghai Institute of Biochemistry and Cell Biology,The Chinese Academy of Sciences,Shanghai,200031,China Kun Yao,Department of Microbiology and Immunology,Nanjing Medical University,Nanjing,210029,Jiangsu Province,China 
the Creation Foundation of Nanjing Medical University,No.Cx9905
AIM: To kill CEA positive colorectal carcinoma cells specifically using the E coli cytosine deaminase (CD) suicide gene, a new replication-deficient recombinant adenoviral vector was constructed in which CD gene was c...
关键词:Gene Therapy Genetic Vectors ADENOVIRIDAE Animals ANTIMETABOLITES Bystander Effect Carcinoembryonic Antigen Cell Line Colorectal Neoplasms Cytosine Deaminase FLUCYTOSINE Hela Cells Humans Nucleoside Deaminases Promoter Regions (Genetics) Research Support  Non-U.S. Gov't Tumor Cells  Cultured 
In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models
《Chinese Medical Journal》2002年第2期227-231,152-153,共5页张正望 殷莲华 张永康 赵凤娣 
OBJECTIVE: To investigate the antitumor and anti-metastatic effect of in situ transduction of adenovirus encoding cytosine deaminase (AdCD) followed by the systemic use of 5-fluorocytosine (5-FC) in the orthotopic (o....
关键词:ADENOVIRIDAE Animals Cell Division Cytosine Deaminase Disease Models  Animal FLUCYTOSINE Lymphatic Metastasis Male MICE Mice  Inbred C57BL Neoplasm Transplantation Nucleoside Deaminases Prostatic Neoplasms Survival Rate Transfection Tumor Cells  Cultured 
Apoptosis induced by 5-flucytosine in human pancreatic cancer cells genetically modified to express cytosine deaminase
《Acta Pharmacologica Sinica》2000年第7期81-85,共5页张世能 袁世珍 朱兆华 文卓夫 黄志清 曾志勇 
To elucidate the pattern of 5-flucytosine (5-FC)-induced apoptosis and its role in gene therapy of human pancreatic cancer. METHODS: The human pancreatic cancer SW1990 cells (CEA-producing) were infected with recombin...
关键词:APOPTOSIS FLUCYTOSINE fluorouracil pancreatic neoplasms DNA fragmentation flow cytome-try gene therapy cytosine deaminase 
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