VORICONAZOLE

作品数：38被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：陈恳杨会霞易湛苗翟所迪冯丽娟更多>>
相关机构：北京大学第三医院清华大学玉泉医院北京大学北京大学第一医院更多>>
相关期刊：《Journal of Intensive Medicine》《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金教育部“新世纪优秀人才支持计划”北京市自然科学基金更多>>
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Disseminated liver histoplasmosis in an immunocompetent individual cured by liver transplantation and voriconazole from China:A case report
《World Journal of Gastroenterology》2025年第9期146-153,共8页Chen-Xuan Li Hao-Dong Chen Shakoor Kashif Bin Xie Jing Luo Ting Li 
BACKGROUND Histoplasmosis is a rare infectious condition with mainly pulmonary involvement which is generally self-limiting in immunocompetent individuals.Its manifestation varies and lacks specificity.This study repo...
关键词：HISTOPLASMA Disseminated histoplasmosis IMMUNOCOMPETENCE Liver transplantation VORICONAZOLE Case report 
Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota
《Journal of Clinical and Translational Hepatology》2024年第5期481-495,共15页Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan Liangbin Zhou Chenyu Zhao Kit Hang Wu Xixiao Yang Jinbin Wei Maoxun Yang 
supported by the Discipline Construction Project of Guangdong Medical University(No.4SG22009G);the Funds for PhD Researchers of Guangdong Medical University in 2021(No.GDMUB2021021);the Dongguan science and technology commissioner project(20231800500332);the Guangdong province ordinary university characteristic innovation project(2020KTSCX341);the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515111116);the Science and Technology Special Fund Project of Guangdong Province in 2021(No.2021A05199);the Shenzhen Foundation of Science and Technology(Nos.JCYJ20230807151308018 and JCYJ20190814112205770);the Zhanjiang Science and Technology Project(2023B01176);Shenzhen Longhua District Science and Technology Innovation Fund Projects(Nos.2022045,2022051,2022056,2022095,2022123,2021105,2021115 and 2020036);the Research Foundation of Shenzhen Longhua District Central Hospital(No.202203).
Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical challenge.Previous studies demonstrated that Astragalus polysaccharide(APS)can regu...
关键词：Astragalus polysaccharide VORICONAZOLE METABOLISM RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota HEPATOTOXICITY 
Determination of Voriconazole in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry: Application in Therapeutic Drug Monitoring
《American Journal of Analytical Chemistry》2023年第9期378-389,共12页Waleed Alhussaini Ezzeldeen Ghanem Magd Alsahly Amani Kurdi Eman Alharbi Imadul Islam Majed Aljeraisy 
A sensitive, accurate and robust Liquid Chromatography Tandem Mass Spectrometry method has been developed and validated to measure voriconazole trough levels in human plasma. The plasma samples were mixed with flucona...
关键词：VORICONAZOLE Human Plasma Liquid Chromatography Tandem Mass Spectrometry Therapeutic Drug Monitoring 
Progress in diagnosis and treatment of invasive aspergillosis after liver transplantation
《Journal of Hainan Medical University》2023年第15期67-72,共6页PAN Sheng-hui SUN Jiang-bo XU Jian 
Major Science and Technology Project of Hainan Province(No.ZDK2019009)。
Invasive aspergillosis is an opportunistic fungal infection disease,and the risk factors of Invasive aspergillosis after liver transplantation are increasing,which seriously affects the quality of life of patients.Inv...
关键词：Liver transplantation Invasive aspergillosis GALACTOMANNAN Next-Generation Sequencing VORICONAZOLE 
Investigation into the structures and physicochemical properties of multi-component crystals of voriconazole
《Chinese Chemical Letters》2023年第6期504-511,共8页Hong-Mei Yu Bao-Xi Zhang Wen-Hui Xing Mei-Ju Liu Feng-Feng Wang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du 
supported by Beijing Natural Science Foundation(No.7222261);Key R&D Program of Shan Dong Province(No.2021ZDSYS26);the Fundamental Research Funds for the Central Universities(No.2021-RW350-001);the Xinjiang Uygur Autonomous Region Innovation Environment Construction Special Fund;Technology Innovation Base Construction Key Laboratory Open Project(No.2022D04016)。
Voriconazole(VZL)is a second-generation and broad-spectrum triazole against fungal infections.Being a BCS(biopharmaceutics classification system)class II compound,the poor aqueous solubility has limited its bioavailab...
关键词：Multi-component crystal VORICONAZOLE SOLUBILITY DISSOLUTION Stability 
Evidence of voriconazole pharmacokinetic variability in children and adolescents with haematological disease: proposal for therapeutic drug monitoring optimisation
《Toxicology Advances》2023年第1期16-23,共8页Pauline Lancia Yves Medard Evelyne Jacqz-Aigrain Tiphaine Adam de Beaumais 
Objective:Voriconazole(VCZ)is a triazole antifungal agent widely used in immunocompromised patients with suspected or proven invasive fungal infections.The achievement of therapeutic range(1-5 mg/L)is essential to max...
关键词：VORICONAZOLE PHARMACOKINETICS VARIABILITY therapeutic drug monitoring PAEDIATRIC HAEMATOLOGY 
CYP2C19 Genotyping Plus Therapeutic Drug Monitoring Dependent Voriconazole Treatment for Invasive Pulmonary Aspergillosis in a Patient with Liver Failure
《Infectious Diseases & Immunity》2022年第2期125-128,共4页Chuan Shen Qian Zhao Ziyue Li Wei Wang Yalin Zhao Lingya Kong Jing Xie Caiyan Zhao 
This work was supported by the National Natural Science Foundation of China(No.81900536).
Invasive pulmonary aspergillosis(IPA)is a lethal infectious disease with high mortality in patients with liver failure.Early recognition of the risk factors prompting earlier diagnosis and treatment may improve the ou...
关键词：Invasive pulmonary aspergillosis Liver failure Therapeutic drug monitoring VORICONAZOLE 
Scedosporium apiospermum infection of the lumbar vertebrae:A case report被引量：1
《World Journal of Clinical Cases》2022年第10期3251-3260,共10页Xue-Wen Shi Sheng-Tang Li Jin-Peng Lou Bo Xu Jian Wang Xin Wang Hua Liu Song-Kai Li Ping Zhen Tao Zhang 
Supported by Chinese People’s Liberation Army Medical Technology Youth Training Program,No. 20QNPY071
BACKGROUND Scedosporium apiospermum(S.apiospermum)is a clinically rare and aggressive fungus mainly found in contaminated water,wetlands,decaying plants,stagnant water,and potted plants in hospitals.The lung,bone,join...
关键词：Scedosporium apiospermum Lumbar vertebrae Fungal infection TREATMENT VORICONAZOLE Case report 
Voriconazole-associated periostitis:Pathophysiology,risk factors,clinical manifestations,diagnosis,and management被引量：1
《World Journal of Transplantation》2021年第9期356-371,共16页Anthony J Guarascio Nitin Bhanot Zaw Min 
Voriconazole use has been associated with osteoarticular pain and periostitis,likely due to high fluoride content in the drug formulation.This phenomenon has been described primarily with high dosage or prolonged cour...
关键词：VORICONAZOLE PERIOSTITIS FLUORIDE FLUOROSIS Alkaline phosphatase 
Disseminated Fusarium bloodstream infection in a child with acute myeloid leukemia:A case report被引量：1
《World Journal of Clinical Cases》2021年第21期6049-6055,共7页Jun-Jie Ning Xue-Mei Li Sheng-Qiu Li 
BACKGROUND Disseminated Fusarium is rare in healthy children.Children with hematological tumors may have secondary fungal infections,including Fusarium infections,which are due to tumor bone marrow infiltration or pro...
关键词：FUSARIUM Liposomal amphotericin B VORICONAZOLE Acute myeloid leukemia AGRANULOCYTOSIS Case report 
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