Voriconazole-associated periostitis:Pathophysiology,risk factors,clinical manifestations,diagnosis,and management  

作　　者：Anthony J Guarascio Nitin Bhanot Zaw Min 

机构地区：[1]Department of Pharmacy,Duquesne University School of Pharmacy,Pittsburgh,PA 15282,United States [2]Division of Infectious Disease,Medicine Institute,Allegheny General Hospital,Allegheny Health Network,Pittsburgh,PA 15212,United States

出　　处：《World Journal of Transplantation》2021年第9期356-371,共16页世界移植杂志

摘　　要：Voriconazole use has been associated with osteoarticular pain and periostitis,likely due to high fluoride content in the drug formulation.This phenomenon has been described primarily with high dosage or prolonged course of voriconazole therapy in immunocompromised and transplant patient populations.Patients typically present with diffuse bony pains associated with elevated serum alkaline phosphatase and plasma fluoride levels in conjunction with radiographic findings suggestive of periostitis.We provide a comprehensive review of the literature to highlight salient characteristics commonly associated with voriconazole-induced periostitis.

关 键 词：VORICONAZOLE PERIOSTITIS FLUORIDE FLUOROSIS Alkaline phosphatase 

分 类 号：R97[医药卫生—药品]