75例非小细胞肺癌患者同步放化疗致放射性肺炎的相关因素分析  

The Correlative Factors of Radiation Pneumonitis Induced by Concurrent Chemoradiotherapy for 75 Cases of Non-small Cell Lung Cancer

作　　者：陈伟明 张志敏[2] 杨镇洲[2] 顾咸庆[2] 陈川[2] 蒋永容[2] 王阁[2] 

机构地区：[1]广东省广州市同和解放军疗养院,广州510515 [2]第三军医大学大坪医院野战外科研究所肿瘤中心,重庆400042

出　　处：《肿瘤预防与治疗》2011年第6期311-314,共4页Journal of Cancer Control And Treatment

摘　　要：目的:探讨非小细胞肺癌同步放化疗引起放射性肺炎的相关影响因素。方法:回顾性分析我中心75例非小细胞肺癌进行三维适形放疗同步化疗后出现放射性肺炎的患者的一般情况,基础肺功能及其放疗靶体积和放疗剂量的关系。结果:75例患者中肿瘤完全缓解(CR)6例,占8%;部分缓解(PR)41例,占54.67%;稳定(NC)17例,占22.67%;进展(PD)11例,占14.67%。肿瘤临床获益率为85.33%。75例肺癌患者治疗后19例出现放射性肺炎,发生率为25.3%。其中患者的一般情况包括年龄及其放疗靶体积、放疗剂量和肺V20与放射性肺炎发生相关,是本组肺癌患者放化同步治疗后放射性肺炎发生的危险因素。结论:肺部基础情况差、放疗靶体积和靶区高剂量的非小细胞肺癌患者接受同步放化疗后易发生放射性肺炎。Objective： To evaluate the correlative factors of radiation pneumonitis （RP）induced by concurrent chemoradiotherapy for non-small cell lung cancer （NSCLC）. Methods ： Clinical data of 75 NSCLC patients who got the RP after being treated with 3DCRT combined with concurrent chemotherapy were retrospectively analyzed. Multivariate analysis was performed to detect the association between RP and the clinical factors. Results： Of the 75 cases , 6 cases got CR（8% ）, 41 PR （54. 67% ）, 17 NC （22. 67% ）, and 11 PD （ 14. 67% ）. Clinical symptoms of RP were found in 19 cases （25.3%） of the 75 patients. Age of patient, target volume of radiation, the radiation dose for gross tumor volume and lung V20 were independently associated with RP according to the multivariate analysis. Conclusion： The NSCLC patients who have poor lung conditions and have accepted high radiation dose for target volume and gross tumor volume combined with concurrent chemotherapy tend to get RP.

关 键 词：非小细胞肺癌 三维适形放疗 化疗 放射性肺炎 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]