复方蛹虫草制剂对慢性疲劳综合症小鼠的治疗作用  

Therapeutic effect of compound Cordyceps militaris on Chronic Fatigue Syndrome mouse induced by poly I:C

作　　者：季锡中[1] 宁青[1] 谈唯[1] 张润桐[1] 贾晓斌[1] 

机构地区：[1]江苏省中医药研究院中药新型给药系统重点实验室/国家中医药管理局中药口服释药系统重点研究室,江苏南京210028

出　　处：《中国民族民间医药》2011年第22期39-41,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:通过小鼠腹腔注射poly I:C模拟病毒感染,复制一种免疫诱导的慢性疲劳模型,考察蛹虫草复方制剂(CCM)对慢性疲劳综合症小鼠的治疗作用。方法:观察小鼠游泳能力、自发活动、学习能力、血清皮质酮水平以及免疫力相关指标。结果:力竭游泳实验中蛹虫草复方高剂量组具有明显的抗疲劳作用(P<0.05),并且能够显著增加小鼠自发活动和学习能力(P<0.05),同时拮抗polyI:C导致的小鼠血清皮质酮水平降低(P<0.05);该复方对小鼠胸腺重量增加无明显影响,但抑制脾脏增大;能够降低CD4+/CD8+比例并且增强T淋巴细胞增殖能力(P<0.05)。结论:以上结果表明蛹虫草复方对慢性疲劳综合症有一定的防治作用。To determine the therapeutic effect of compound Cordyceps militaris （CCM） on mouse Chronic Fatigue Syndrome （CFS） induced by intraperitoneal injection of poly I： C. METHODS： Forced swimming test and immune systems were evaluated. RE- SULTS ： CCM （0. 6, 1. 1, 3. 4 g crud drug/kg weight）, orally administered, showed dose - dependent anti - fatigue effects. High dosage group of CCM improved the abnormalities caused by poly I： C, and restored the function of hosts to normal （P 〈 0. 05）. High dosage group of CCM significantly improved the immunological abnormalities caused by poly I ： C through reducing the CD4 ＋/CD8 ＋ ratio in the peripheral blood and reversing the hyporesponsiveness of T cells in spleens （ P 〈 0. 05 ）. CONCLUSION ： These findings suggested that CCM was beneficial for CFS.

关 键 词：蛹虫草 聚肌胞 慢性疲劳综合症 免疫 

分 类 号：R965.2[医药卫生—药理学]