细胞核形态定量在小细胞肺癌的纤支镜细胞学中的应用研究  

Application of cell nucleus morphometry in the bronchofiberscope brush cytology of small cell lung cancer

作　　者：王文清[1] 郭华雄[1] 龚平[1] 赵廷宽[1] 李春燕[1] 

机构地区：[1]华中科技大学同济医学院附属荆州医院(荆州市中心医院)病理科,434020

出　　处：《实用医学杂志》2011年第22期4048-4050,共3页The Journal of Practical Medicine

基　　金：荆州市医疗卫生科技发展计划项目资助(2009年度)(编号:2009-13-19)

摘　　要：目的:探讨基于纤维支气管镜刷片细胞涂片中,多参数的细胞核形态定量分析对小细胞肺癌与非小细胞肺癌的鉴别诊断价值。方法:利用HMIAS-2000医学图文分析测量系统,对组织学确诊的纤维支气管镜刷片的小细胞肺癌与非小细胞肺癌的细胞核进行形态定量研究(腺癌48例、鳞癌28例、小细胞癌22例,阴性对照组40例)。结果:在22个形态定量参数中,小细胞肺癌与良性对照20项参数有显著统计学差异(P<0.05),小细胞肺癌与非小细胞肺癌16项有统计学差异(P<0.05)。结论:小细胞肺癌的多参数的形态计量揭示了纤支镜刷片细胞学的细胞核形态学计量特征,对辅助鉴别诊断小细胞肺癌具有一定的意义。Objective To investigate the differential diagnostic value of the quantitative analysis on the cell nucleus morphometry in the bronchofiberscope cytological brush for small cell lung cancer （SCLC）. Methods By high multimedia image and word analysis system （HMIAS 2000）, cell nucleus from SCLC tissues （22 cases）, non small cell lung cancer tissues （76 cases） and benign lesions （40 cases） were quantitatively stereological studied with muhi parameters. Results In all the 22 parameters, there were significant differences of 20 parameters between benigh lesions and small cell lung cancer between SCLC and benign lesions （P 〈 0.05）, and of 16 parameters between SCLC and NSCLC （P〈 0.05）. Conclusion The morphological characteristics of SCLC, NSCLC, and benign lesion were present by cell nucleus morphometry in the bronchofiberscope brush cytology of SCLC, which is valuable for the differential diagnosis for SCLC.

关 键 词：肺肿瘤 纤支镜刷片 细胞学 细胞核 多参数 定量研究 

分 类 号：R734.2[医药卫生—肿瘤]