伴侣分子抗原肽瘤苗的抗肿瘤机制  

Anti-tumor mechanisms of companion member antigen peptide tumor vaccine

作　　者：姜贻乾[1] 黄常新[2] 李朝阳[1] 段广亮[1] 

机构地区：[1]浙江中医药大学内科学2009级研究生,杭州310015 [2]杭州师范大学附属医院肿瘤科

出　　处：《国际肿瘤学杂志》2011年第11期829-833,共5页Journal of International Oncology

基　　金：国家自然科学基金资助项目（81072495;）

摘　　要：伴侣分子抗原肽瘤苗因其化学性质稳定、易于制备、无潜在致癌性等优点，受到广泛关注。伴侣分子抗原肽瘤苗可通过伴侣分子的抗原提呈、增强机体的非特异性抗肿瘤机制以及激活特异性肿瘤免疫机制等多种途径发挥作用，其抗肿瘤机制的多样性等优点在肿瘤的临床免疫治疗中将有着积极的作用。With the continuous development of tumor immunology, cancer vaccines have become a hot spot of tumor immunotherapy. Companion member antigen peptide tumor vaccine attracts widely attention because of its chemical stability, easy preparation and no carcinogenic potential advantage. Companion member antigen peptide tumor vaccine may work through many kinds of ways including the function of antigen presenting, enhancing the body＇s non-specific line of anti-tumor mechanisms and activating the tumor-specific immune mechanism. Its different anti-tumor mechanisms merits and so on will have positive function in the tumor clinical immunity treatment.

关 键 词：热休克蛋白质类 抗原 肿瘤 

分 类 号：R730.3[医药卫生—肿瘤]