上皮-间质转化与胰腺癌生物学行为的关系  

RELATIONSHIP BETWEEN EPITHELIAL-MESENCHYMAL TRANSITION AND BIOLOGICAL BEHAVIOR OF PANCREATIC CANCER

作　　者：张红梅[1] 王骥平[2] 陈德利[3] 

机构地区：[1]青岛市第八人民医院,山东青岛266100 [2]青岛市市立医院急诊普外科 [3]青岛大学医学院附属医院药剂科

出　　处：《齐鲁医学杂志》2011年第6期474-475,478,共3页Medical Journal of Qilu

摘　　要：目的探讨上皮-间质转化(EMT)在胰腺癌浸润转移中的作用。方法采用免疫组织化学PV 6000法检测47例胰腺癌组织上皮-钙黏蛋白(E-cad)和波形蛋白(Vim)的表达。把E-cad阴性-Vim阳性表达作为癌细胞发生EMT的免疫表型。结果 47例胰腺癌组织中E-cad和Vim阳性率分别为46.8%、23.4%,其中E-cad阴性-Vim阳性表达7例,EMT发生率为19.1%。EMT发生率与胰腺癌的分化程度和转移有关(χ2=6.73、4.06,P<0.05),与临床分期和1年生存率无关(χ2=3.56、2.72,P>0.05)。结论 EMT在胰腺癌的分化、浸润和转移过程中起重要作用。Objective To assess the role of epithelial-mesenchymal transition（EMT） in infiltration and metastasis of pancreatic cancer.Methods Immunohistochemical PV 6000 technique was used to detect the expressions of E-cadherin（E-cad） and Vimentin（Vim） in 47 cases of pancreatic cancer tissue.Results The positive rates of E-cad and Vim were 46.8% and23.4%,respectively,in 47 cases of pancreatic cancer tissue,of which,the E-cad negative-Vim positive expression seven cases,EMT incidence was 19.1%.The EMT was associated with the cancer cell differentiation and metastasis（χ^2=6.73,4.06;P〈0.05）,but not related with clinical stage and one-year survival rate（χ^2=3.56,2.72;P〉0.05）.Conclusion The EMT plays an important role in cell differentiation,invasion and metastasis of pancreatic carcinoma.

关 键 词：胰腺肿瘤 上皮-间质转化 桥粒钙黏蛋白质类 波形蛋白 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]