52例胃癌组织中Survivin和Bcl-2蛋白表达研究  

Expressions of Survivin and Bcl-2 protein in 52 specimens of gastric carcinoma tissue

作　　者：李冬霞[1] 司艳莉[1] 邓晓慧[2] 冯艳玲[3,4] 

机构地区：[1]新乡医学院机能实验室,上海201508 [2]新乡医学院解剖教研室,河南新乡453003 [3]新乡医学院 [4]复旦大学附属公共卫生临床中心病理科,上海201508

出　　处：《重庆医学》2011年第22期2206-2207,2210,F0003,共4页Chongqing medicine

基　　金：河南省自然科学研究基金资助项目(2006310010);新乡医学院高学历资助项目(08sskyqd-015)

摘　　要：目的探讨胃癌组织中Survivin及Bcl-2蛋白的表达及其与胃癌生物学行为的关系。方法采用免疫组化SP法检测52例胃癌组织、30例正常胃黏膜组织中Survivin及Bcl-2蛋白的表达。结果 Survivin、Bcl-2蛋白在胃癌组织中的阳性表达均高于正常胃黏膜(P<0.05);Survivin、Bcl-2蛋白表达均分别与胃癌的分化程度、淋巴结转移有关(P<0.05)。结论 Survivin、Bcl-2蛋白表达上调可能与胃癌的发生、发展有关,二者共同作用抑制凋亡。Objective To investigate the expressions of Survivin and Bcl-2 protein in gastric carcinoma and their relationships with carcinomatous biological behaviour.Methods The expressions of Survivin and Bcl-2 protein were detected in 52 cases of surgically resected gastric carcinoma specimens and 30 cases of corresponding normal mucosa tissues using the immunohistochemistry S-P method.Results The expressions of Survivin and Bcl-2 protein in tumor tissues were significantly higher than those in adjacent mucosa tissues（P0.05）.Survivin and Bcl-2 protein expressions were correlated with tumor differentiation and lymph node metastasis（P0.05）.Conclusion Overexpressions of Survivin and Bcl-2 correlate with occurrence and development of gastric carcinoma,and their interaction inhibits apoptosis.

关 键 词：胃肿瘤 胃黏膜 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]