Chemometrics and modernization of traditional Chinese medicine  

作　　者：LIANG YiZeng YI LunZhao XU QingSong 

机构地区：[1]Research Center of Modernization of Traditional Chinese Medicine,Central South University,Changsha 410083,China [2]College of Mathematics,Central South University,Changsha 410083,China

出　　处：《Science China Chemistry》2008年第8期718-728,共11页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation China (Grant Nos. 20475066 and 10771217);the International Cooperation Project on Traditional Chinese Medicines of Ministry of Science and Technology of China (Grant Nos. 2006DFA41090 and 2007DFA40680)

摘　　要：Development of chromatographic fingerprinting and its related chemometric methods in the research of quality control of traditional Chinese medicines(TCMs) are discussed. The quality control methods for guarantying the authentication and stability of products and semi-products of TCMs are firstly assessed. The technique based on chromatographic fingerprinting is essentially a kind of high-through put and integral tools to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs,confirmation and identification of their important chemical components are necessary. Some new strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with systems biology and bioinformatics,it seems possible for one to reveal the working mechanism of TCMs and to further control their intrinsic quality comprehensively.Development of chromatographic fingerprinting and its related chemometric methods in the research of quality control of traditional Chinese medicines (TCMs) are discussed. The quality control methods for guarantying the authentication and stability of products and semi-products of TCMs are firstly assessed. The technique based on chromatographic fingerprinting is essentially a kind of high-throughput and integral tools to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs, confirmation and identification of their important chemical components are necessary. Some new strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with systems biology and bioinformatics, it seems possible for one to reveal the working mechanism of TCMs and to further control their intrinsic quality comprehensively.

关 键 词：MODERNIZATION of TRADITIONAL Chinese MEDICINE CHEMOMETRICS CHROMATOGRAPHIC fingerprinting QUALITY control 

分 类 号：R284[医药卫生—中药学] R2-03[医药卫生—中医学]