Simultaneous kinetic spectrophotometric determination of norfloxacin and rifampicin in pharmaceutical formulation and human urine samples by use of chemometrics approaches  

作　　者：KOKOT Serge 

机构地区：[1]School of Physical and Chemical Sciences,Queensland University of Technology,Brisbane 4001,Australia

出　　处：《Science China Chemistry》2008年第8期776-785,共10页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 20562009);Opening Fund from the State Key Lab of Chemo/Biosensing and Chemometrics (Hunan University) (Grant No. 2005-22);Jiangxi Province Natural Science Foundation (Grant No. 0620041);Program for Changjiang Scholars and Innovative Research Team in Universities (Grant No. IRT0540)

摘　　要：A kinetic spectrophotometric method with aid of chemometrics is proposed for the simultaneous determination of norfloxacin and rifampicin in mixtures. The proposed method was applied for the simultaneous determination of these two compounds in pharmaceutical formulation and human urine samples,and the results obtained are similar to those obtained by high performance liquid chromatography.A kinetic spectrophotometric method with aid of chemometrics is proposed for the simultaneous determination of norfloxacin and rifampicin in mixtures. The proposed method was applied for the simultaneous determination of these two compounds in pharmaceutical formulation and human urine samples, and the results obtained are similar to those obtained by high performance liquid chromatography.

关 键 词：CHEMOMETRICS KINETIC SPECTROPHOTOMETRIC determination norfloxain RIFAMPICIN 

分 类 号：R96[医药卫生—药理学]