依达拉奉联用降纤酶治疗急性脑梗死临床研究  

Clinical study of edaravone-defibrase combination in treatment of acute cerebral infarction

作　　者：龙威[1] 谢娟[1] 唐建国[1] 张羽[1] 张奕翠[1] 陆刚[1] 陆伟[1] 

机构地区：[1]复旦大学附属上海市第五人民医院急诊科,上海200240

出　　处：《中国实用内科杂志》2008年第S1期68-70,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的研究依达拉奉联用降纤酶治疗急性脑梗死的临床疗效及安全性。方法选择2005—2007年复旦大学附属上海市第五人民医院急诊科发病12h内的急性脑梗死患者93例,随机分为A组46例和B组47例。A组患者使用依达拉奉注射液(30mg加入生理盐液100mL静脉滴注,每日2次,共14d)和降纤酶(首剂量为15U,以后隔日5U,共4次,均加入生理盐液250mL,2～3h内静脉滴注);B组仅使用降纤酶治疗。治疗前后对患者进行欧洲脑卒中量表(ESS)神经功能缺损程度评分、日常生活能力(ADL)、APACHEⅡ评分及C-反应蛋白(CRP)的测定,治疗后进行疗效评定,进行为期3个月的随访。结果在治疗后14d,两组患者的ESS、ADL、A-PACHEⅡ和CRP较治疗前有显著改善,A组的各项指标优于B组;A组有效率(67.4%)高于B组(40.4%)(P<0.05);两组的3个月病死率没有显著差异(P>0.05);两组患者均无颅内出血发生,少数患者发生颅外出血,两组没有显著差异,所有病例无严重不良反应发生。结论依达拉奉联用降纤酶能够安全有效的治疗急性脑梗死患者。Objective To investigate the efficacy and safety of edaravone-defibrase combination in treatment of acute cerebral infarction.MethodsThe patients with acute cerebral infarction within 12 hours of stroke onset were divided randomly into two groups:group A(46 cases)and group B(47 cases).Group A were treated with edaravone(30 mg,twice a day,for 14 days)and defibrase(initial 15U,subsequent 5U on the 3th,5th,7th,9th day);and group B were treated only with defibrase.The neurological deficit scores of European stroke scale(ESS),activities of daily living(ADL),APACHE Ⅱ scores and C-reactive protein(CRP)level were evaluated before and after treatment;the efficacy was evaluated after the treatment.ResultsAfter the 14th day treatment,there were significant difference of all the four variables(ESS,ADL,APACHE Ⅱ and CRP)in two groups than before treatment,all the four variables of group A were better than group B;the efficient rate of group A(67.4%)was higher than group B(40.4%)(P<0.05);there was no significant difference for the mortality at 3 months between two groups(P>0.05);There were several patients with extracranial hemorrhage and there was no significant difference between two groups(P>0.05),there was no intracranial hemorrhage in all patients;there was no severe adverse reaction in two groups.ConclusionEdaravone-defibrase combination is effective and safe in treatment of acute cerebral infarction.

关 键 词：依达拉奉 降纤酶 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]