低分子量肝素对脑梗死患者血液流变学的影响  

Hemorheological Influence of Low Molecular weight heparin on cerebral infarction patients

作　　者：徐朴[1] 周佑德[1] 严翔[1] 李锋[1] 

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《临床血液学杂志（输血与检验）》2007年第4期165-166,168,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:观察低分子量肝素对脑梗死的临床疗效和血液流变学的影响。方法:随机选取32例经临床确诊的脑梗死患者,给予低分子量肝素和脑保护剂治疗,在治疗前后检测血液流变学特性,并进行临床疗效观察。结果:经低分子量肝素治疗后,患者全血高切黏度(P=0.0008)、全血低切黏度(P=0.0009)、血浆黏度(P=0.0008)、红细胞压积(P=0.0351)、血沉(P=0.0093)、全血高切还原黏度(P=0.0007)、全血低切还原黏度(P=0.0008)、红细胞聚集指数(P=0.0075)均显著降低,治疗总有效率达87.5%。结论:低分子量肝素可以有效地改善脑梗死患者的血液高凝状态,疗效显著。Objective:To observe the clinical curative effect and hemorheological influence of low molecular weight heparin on treating cerebral infarction.Methods:32 cases with cerebral infarction were randomly selected and treated with low molecular weight heparin and cerebral protective drugs. At the same time, the hemorheological examination and observation of clinical curative effect were done before and after treatment. Results:The patients' blood high shear viscosity(P=0.0008) , blood low shear viscosity (P=0.0009),plasma viscosity (P=0.0008),hematocrit(P=0.0351), erythrocyte sedimentation rate(P=0.0093), blood high shear reductive viscosity(P=0.0007), blood low shear reductive viscosity (P=0.0008) and erythrocyte aggregation index(P=0.0075) were remarkable lower than those before treatment. The total effective rate was 87.5% after treatment. Conclusion:Low molecular weight heparin may effectively improve the blood hypercoagulabale state of patients with cerebral infarction. Its clinical curative effect is notable.

关 键 词：低分子量肝素 脑梗死 血液流变学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]