Study on Mechanical and Biological Properties of Autopolymerizing Hydrogel for Denture Soft Lining Material  

作　　者：SUN Jiao,XUE Miao ,HE Wei 

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》2003年第3期111-118,共8页中国生物医学工程学报（英文版）

摘　　要：Objectives: To investigate the water sorption, solubility, bond strength and biocompatibility of a new kind of compound autopolymerizing hydrogel [polyhydroxyethyl methacrylate (PHEMA) and polybutyl methacrylate (PMBA)] designed for denture soft lining material. Methods: According to ISO standard, the water sorption, solubility, bond strength and a series of biological evaluation for this hydrygel were tested, and in bond strength, the plasticized acrylic and SDG-A silicone denture soft lining materials were used for comparative materials. Results: It showed that hydrogel had much higher bond strength with denture base acrylic resin (7.984 Mpa) when compared with plasticized acrylic and SDG-A silicone soft lining material. There was a good biocompatibility in all biological tests. No cytotoxic, allergic, acute systemic toxic, oral mucous membrane irritant, genotoxic and heamolysis activity was demonstrated. It also indicated the absorption and solubility in distilled water were higher than those in artificial saliva at the same stage (at 7 d and 28 d ). There was statistical significance between them (P<0.01). It had higher water sorption (24.96%) and lower solubility (0.51%) at 28 d. Further clinical study is needed to verify the dimensional stability. Significance: It is to develop a kind of denture soft lining material which presenting a good bond strength with base resin and keeping soft properties for a long time.Objectives: To investigate the water sorption, solubility, bond strength and biocompatibility of a new kind of compound autopolymerizing hydrogel [polyhydroxyethyl methacrylate (PHEMA) and polybutyl methacrylate (PMBA)] designed for denture soft lining material. Methods: According to ISO standard, the water sorption, solubility, bond strength and a series of biological evaluation for this hydrygel were tested, and in bond strength, the plasticized acrylic and SDG-A silicone denture soft lining materials were used for comparative materials. Results: It showed that hydrogel had much higher bond strength with denture base acrylic resin (7.984 Mpa) when compared with plasticized acrylic and SDG-A silicone soft lining material. There was a good biocompatibility in all biological tests. No cytotoxic, allergic, acute systemic toxic, oral mucous membrane irritant, genotoxic and heamolysis activity was demonstrated. It also indicated the absorption and solubility in distilled water were higher than those in artificial saliva at the same stage (at 7 d and 28 d ). There was statistical significance between them (P<0.01). It had higher water sorption (24.96%) and lower solubility (0.51%) at 28 d. Further clinical study is needed to verify the dimensional stability. Significance: It is to develop a kind of denture soft lining material which presenting a good bond strength with base resin and keeping soft properties for a long time.

关 键 词：HYDROGEL SOFT LINING material Water SORPTION Solubility Bond strength BIOCOMPATIBILITY 

分 类 号：R318.08[医药卫生—生物医学工程]