BDI-1-MT治疗膀胱癌及预防其术后复发的临床观察  

CLINICAL OBSERVATION OF BDI-1-MT FOR THE TREATMENT OF BLADDER CARCINOMA AND PREVENTION OF CURRENCE AFTER SURGERY

作　　者：崔嘉陵[1] 郝吉林[1] 陈焱[1] 黄燕林[1] 包建成[1] 王鹏龙[1] 谢蜀生[2] 高翔[2] 

机构地区：[1]包头医学院第三附属医院,内蒙古包头014030 [2]北京大学医学部免疫学系,北京100083

出　　处：《中国医师进修杂志》2003年第20期13-15,共3页Chinese Journal of Postgraduates of Medicine

基　　金：20 0 1年包头市医药卫生基金会资助课题

摘　　要：目的　通过临床应用膀胱腔内灌注抗人膀胱癌免疫毒素 (BDI- 1-MT) ,观察治疗膀胱癌和预防膀胱癌术后复发的效果及毒副反应。方法　对 18例术后和 5例未手术的膀胱癌病人 ,膀胱腔内灌注BDI- 1-MT 1个疗程以上 ,观察疗效、复发情况及毒副反应。结果　术后 18例随访 6～ 2 0个月未见复发 ,未手术 5例随访 6～ 2 1个月 ,其中 3例显效 ,2例有效。所有病例均无明显毒副反应。结论　膀胱腔内灌注BDI- 1-MT治疗膀胱癌和预防膀胱癌术后复发有良好效果 ,是一种值得推广的新方法。Objective To observe the clinical efficacy of BDI-1-MT for the treatment of bladder carcinoma and the role of BDI-1-MT for the prevention of currence and the side effects into to the bladders after surgery. Method 23 patients with bladder carcinoma were treated with the instillation of BDI-1-MT into the bladder cavity for more than one course. 18 patients were after surgery and 5 patients were before surgery. The clinical efficacy, currence and side effects were evaluated. Results All 18 patients with surgery were followed up for 6 to 20 months and no one showed recurrence. The 5 patients without surgery were followed up for 6 to 21 months, three patients have been achieved in complete tumor regression and the rest two showed partial effectiveness. All the patients with the application of BDI-1-MT showed no obvious side effects. Conclusion The intravesical instillation of BDI-1-MT has better efficacy for the treatment of bladder carcinoma. This method can also prevent the currence of bladder carcinoma after surgery. The application of BDI-1-MT should be well worth spread.

关 键 词：膀胱癌 膀胱灌注 BDI-1-MT 疗效 毒副反应 

分 类 号：R737.14[医药卫生—肿瘤]