Enthalpy-entropy compensation in protein unfolding  

作　　者：Lei Liu Chao Yang Qingxiang Guo 

机构地区：[1]Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

出　　处：《Chinese Science Bulletin》2000年第16期1476-1480,共5页

摘　　要：Enthalpy-entropy compensation was found to be a universal law in protein unfolding based on over 3 000 experimental data. Water molecular reorganization accompanying the protein unfolding was suggested as the origin-of the enthalpy-entropy compensation in protein unfolding. It is indicated that the enthalpy-entropy compensation constitutes the physical foundation that satisfies the biological need of the small free energy changes in protein unfolding, without the sacrifice of the bio-diversity of proteins. The enthalpy-entropy compensation theory proposed herein also provides valuable insights into the Privalov’s puzzle of enthalpy and entropy convergence in protein unfolding.Enthalpy-entropy compensation was found to be a universal law in protein unfolding based on over 3000 experimental data. Water molecular reorganization accompanying the protein unfolding was suggested as the origin of the enthalpy-entropy compensation in protein unfolding. It is indicated that the enthalpy-entropy compensation constitutes the physical foundation that satisfies the biological need of the small free energy changes in protein unfolding, without the sacrifice of the bio-diversity of proteins. The enthalpy-entropy compensation theory proposed herein also provides valuable insights into the Privalov’s puzzle of enthalpy and entropy convergence in protein unfolding.

关 键 词：enthalpy-entropy COMPENSATION PROTEIN UNFOLDING water molecular reorganization. 

分 类 号：O629[理学—有机化学]