Effect of Buyang Huanwu Decoction (补阳还五汤) on Plasma Thromboxane B_2, 6-Keto-Prostaglandin F_(1α), Endothelin and Calcitonin Gene Related Peptide in Primary Nephrotic Syndrome Patients  

作　　者：吴玉生 杨剑辉 姜立平 王占奎 

出　　处：《Chinese Journal of Integrative Medicine》2000年第1期6-9,共4页中国结合医学杂志（英文版）

摘　　要：Objective: To explore the mechanism of Buyang Huanwu Decoction (BHD) in treating early cerebral infarction. Methods: Seventy cases with early cerebral infarction were randomly divided into two groups. Chinese medicine group (CMG, n=35) was treated with BHD; western medicine group (WMG, n=35) was treated with hydroxyethyl starch injection and enteric coated aspirin tablets. The levels of endothelin (ET) and calcitonin gene related peptide (CGRP) in plasma before and after treatment and the results of clinical treatment were observed.Also healthy subjects were used as the normal control. Results: The levels of ET before treatment in the two treated groups were significantly higher than that of the healthy subjects ( P <0.001), and the levels of CGRP were significantly lower ( P <0.001). After treatment the metabolic imbalance of ET and CGRP improved significantly in the two treated groups ( P <0.001), but the ET and CGRP in CMG improved more obviously than those in WMG ( P <0.01, P <0.05). The markedly effective and curative rate of CMG was higher than that of WMG (68.6% vs 31.4%; χ 2=9.65, P <0.01). Conclusion: BHD could improve the metabolic imbalance of ET and CGRP in patients with early cerebral infarction and on the virtue of this mechanism it could be used to treat cerebral infarction.Objective: To explore the mechanism of Buyang Huanwu Decoction (BHD) in treating early cerebral infarction. Methods: Seventy cases with early cerebral infarction were randomly divided into two groups. Chinese medicine group (CMG, n=35) was treated with BHD; western medicine group (WMG, n=35) was treated with hydroxyethyl starch injection and enteric coated aspirin tablets. The levels of endothelin (ET) and calcitonin gene related peptide (CGRP) in plasma before and after treatment and the results of clinical treatment were observed.Also healthy subjects were used as the normal control. Results: The levels of ET before treatment in the two treated groups were significantly higher than that of the healthy subjects ( P <0.001), and the levels of CGRP were significantly lower ( P <0.001). After treatment the metabolic imbalance of ET and CGRP improved significantly in the two treated groups ( P <0.001), but the ET and CGRP in CMG improved more obviously than those in WMG ( P <0.01, P <0.05). The markedly effective and curative rate of CMG was higher than that of WMG (68.6% vs 31.4%; χ 2=9.65, P <0.01). Conclusion: BHD could improve the metabolic imbalance of ET and CGRP in patients with early cerebral infarction and on the virtue of this mechanism it could be used to treat cerebral infarction.

关 键 词：Buyang Huanwu decoction cerebral infarction ENDOTHELIN calcitonin gene related peptide metabolic imbalance 

分 类 号：R285[医药卫生—中药学]