动脉粥样硬化斑块形成及消退动物实验观察  

Regression of Diet-induced Atherosclerosis in New Zealand Rabbit

作　　者：唐亚辉[1] 马葵[1] 李次芬[1] 

机构地区：[1]海军总医院血液科

出　　处：《转化医学杂志》2000年第1期15-17,共3页Translational Medicine Journal

摘　　要：经过三个月食饵性高血脂对新西兰兔动脉粥样硬化斑块形成诱导后,对斑块的消退又进行了三个月的观察.结果发现,高血脂能引起血小板数增加、粘附力增强、前列环素/血栓素A_2(PGI_2/TXA_2)失衡,纤维蛋白原及纤溶酶原含量增高,脂质过氧化代谢产物丙二醛(MDA)含量升高,且在胸腹主动脉形成明显的脂肪条纹及纤维斑块.在停高脂饮食后的三个月的消退期,血清胆固醇明显下降,上述各指标均显著降低,但组织病理学上提示,形成的斑块并没有消退且略有加重.The regression of diet-induced atherosclerosis in New Zealand white rabbit was investigated after a 3-month induction period. At 1 month after feeding a high-cholesterol diet, levels of BPC, TC, PAdT, TxA Fbg, Pg, MDA had increased rapidly and the high levels were maintained throughout the 3 month induction period. Morphological features showed at 3 months fatty streaks and fibrous plaques in the thoracic aorta. After return to the conventional diet at 3 months, TC decreased rapidly and maintained the baseline level throughout the 3 month regression period. Histopathological findings did not show the regression but light progression.

关 键 词：动脉粥样硬化 消退 新西兰兔 

分 类 号：R543[医药卫生—心血管疾病]