门脉高压性胃病患者血清胃泌素、生长抑素和胰高糖素的研究  

DETECTION OF GASTRIN, GLUCOGAN AND SOMOTOSTATIN IN PORTAL HYPERTENSION GASTROPATHY PATIENTS

作　　者：张翠萍[1] 张琪[1] 杨立廷[1] 杨沁清 

机构地区：[1]青岛医学院附属医院消化科,青岛市266003 [2]山东省乳山市人民医院内科

出　　处：《实用肝脏病杂志》2000年第3期142-143,共2页Journal of Practical Hepatology

摘　　要：目的 探讨肝硬化失代偿期患者多种胃肠激素的变化与门脉高压性胃病发生的关系。方法 采用放射免疫法测定血清胃泌素、胰高糖素、生长抑素的水平。结果 血清胃泌素较正常对照组明显增高、胰高糖素、生长抑素较正常对照组明显降低且随肝功能的变化而增减。结论 肝硬化时各种胃肠激素的失平衡是产生门脉高压性胃病的重要因素,将为预防肝硬化非食道胃底静脉曲张破裂出血提供重要的理论依据。Objective To investigate gastrointestinal endocrine hormones in decompensated cirrhoticpatients. Method The serum levels of gastrin, glucogan and somotostatin were detected by radioim-munoassay. Results The serum gastrin level was significantly higher, while the serum levels of glucogan and somotostatin were significantly lower in patients with PHG than in normal controls. Conclusion The imbalance of various gastrointestinal endocrine hormones plays an important role in the development of portal hyperten-sional gastropathy in cirrhotic patients.

关 键 词：门脉高压 胃病 肝硬化 胃肠激素 

分 类 号：R575.2[医药卫生—消化系统]