联合检测HA、Ⅳ-C、LN对肝纤维化的诊断价值  

DIAGNOSTIC SIGNIFICANCE OF SERUM HA, IV-C AND LN LEVELS IN LIVER FIBROSIS

作　　者：黄团新[1] 周永兴[2] 韩秀珍[2] 姚志强[2] 

机构地区：[1]武警湖北总队医院内三科,武汉市430061 [2]第四军医大学唐都医院

出　　处：《实用肝脏病杂志》2000年第3期147-149,共3页Journal of Practical Hepatology

摘　　要：目的 通过对各型病毒性肝炎患者血清部分肝纤维化指标的检测,以评价其对病毒性肝炎肝纤维化的诊断价值。方法 采用RIA法测定患者直清HA,Ⅳ-C、LN的含量,同时检测肝功能,B超测定门静脉内径。结果 血清HA、Ⅳ-C、LN水平随着慢性肝病的加重而逐渐升高,均显著高于正常对照组。HA、Ⅳ-C、LN联合检测诊断肝纤维化的灵敏度为91.5％,特异度为86.6％,诊断正确率为90.1。结论 HA、Ⅳ-C、LN联合检测对肝纤维化程度的判断有诊断价值。Objective To eveluate the diagnostic significance of serum hyaluronan(HA), type IV collagen (IV-C) and laminin(LN) levels in liver fibrosis induced by viral hepatitis. Methods Using RIA methods,we determined contents of serum HA, IV -C and LN in patients with different types of viral hepatitis. Results It was found that the serum HA, IV -C and LN levels increased in chronic hepatitis and liver cirrhosis and serum levels of HA increased in both acute and chronic hepatitis. Relatively, the three serum parameters didn't'or slightly increased in mild degree of chronic hepatitis. The sensitivity, specificity and accuracy of combination detection HA、IV-C and LN in diagnosis of liver cirrhosis were 91. 5%,86. 6% and 90.1%, respectively. Conclusion: These findings indicate that the serum HA, IV-C and LN Levels may be a noninvasive approach for determination of liver cirrhosis.

关 键 词：肝纤维化 透明质酸 Ⅳ型肝原 层粘蛋白 

分 类 号：R575.2[医药卫生—消化系统]