吉兰-巴雷综合征病人100例电生理学分型分析  

Electrophysiological classification of Guillain-Barre syndrome:analysis of 100 cases

作　　者：江文[1] 徐燕[1] 吴保仁[1] 黄远桂[1] 王洪典[1] 任雪芳[1] 

机构地区：[1]第四军医大学西京医院神经内科,西安710032

出　　处：《中华神经科杂志》2000年第4期41-44,共4页Chinese Journal of Neurology

摘　　要：目的　探讨吉兰 巴雷 (Guillain Barr啨)综合征 (GBS)的电生理学分型及不同电生理亚型的发病特点。方法　回顾分析我院近 2 0年诊断的 10 0例GBS病人的电生理和临床资料 ,应用 χ2 检验比较不同年龄阶段GBS各亚型发病的差异性。结果　 10 0例GBS病人中原发性脱髓鞘型 5 1例 ,原发性轴索型 2 5例 ,神经失电位型 8例 ,不明确型 12例 ,正常型 4例。在不同年龄阶段起病的GBS以及在不同病程阶段检测均以脱髓鞘型为主要形式 ,各年龄组之间GBS亚型构成比差异无显著性意义。GBS病人中病前 32 .0 %患上呼吸道感染 ,2 2 .0 %患消化道感染。农村和城市病例数几乎各占一半 ,未见有明显的城乡分布差异。脱髓鞘型和轴索型GBS全年均有新发病人 ,第三季度发病人数相对为多。结论　在我院就诊的 10 0例GBS病人的主要发病形式是原发性脱髓鞘型 ,各亚型的发病特点与欧美以及河北医学院第二附属医院的结果比较均存在一定的差异。Objective To explore the electrophysiological and clinical features of various subtypes of Guillain Barré syndrome (GBS). Methods The electrophysiological and clinical data of 100 cases with GBS admitted to Xijing Hospital from 1980 to 1999 were analyzed retrospectively. Correlations between varied subtypes and ages were examined by χ 2 test. Results Among the 100 patients with GBS, the demyelinating pattern was present in 51 patients, the axonal pattern in 25 patients, and 8 patients were inexcitable, 12 patients equivocal and 4 patients normal. The demyelinating pattern appeared as a major subtype not only in different age groups, but also in different test times after symptom onset. There was no statistically significant relationship between varied subtypes and ages. In the 100 patients, 32.0% suffered from a preceding upper respiratory infection, and 22.0% had a preceding gastrointestinal tract infection. The cases occurring in rural areas are almost in number equal to those in urban areas. That is, there was no a clear area distribution. Both demylinating and axonal GBS occurred throughout the year with a likely peak from July to September. Conclusion In the 100 patients with GBS admitted to Xijing Hospital, the demyelinating pattern was the major electrophysiological subtype. In addition, the electrophysiological and clinical features of various subtypes of GBS seemed to be different in some ways from those in the studies of both western countries and Li CY in northern China.

关 键 词：多神经根神经炎 电生理学 

分 类 号：R745.43[医药卫生—神经病学与精神病学]