Separation of chiral drugs with β-CD phosphate by capillary electrophoresis  

作　　者：Xue Qin REN1 Xiao Dan SU1 Al Jin HUANG1 Yi Liang SUN1 Zeng Pei SUNZ2 (1 Department of Chemistry, Peking University, Beijing 100871 2 National Institute for the Control of pharmaceutical and Biological Products, Beijing 100050) 

出　　处：《Chinese Chemical Letters》2000年第2期153-156,共4页中国化学快报（英文版）

摘　　要：β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.

关 键 词：Capillary electrophoresis chiral separation β-cyclodextrin-phosphate ISOPRENALINE METHOXAMINE oxprenolol practolol. 

分 类 号：O657.8[理学—分析化学]