ISOPRENALINE

作品数：20被引量：40H指数：3
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相关领域：医药卫生更多>>
相关作者：杨丹蕾李超乾张珍祥徐永健刘先胜更多>>
相关机构：华中科技大学更多>>
相关期刊：《Chinese Medical Journal》《Medical Bulletin of Shanghai Jiaotong University》《World Journal of Cardiovascular Diseases》《Chinese Herbal Medicines》更多>>
相关基金：国家自然科学基金教育部留学回国人员科研启动基金广东省自然科学基金更多>>
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Pleiotropic attenuating effect of Ginkgo biloba against isoprenalineinduced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase activities被引量：1
《Chinese Herbal Medicines》2024年第2期282-292,共11页Jerome Ndudi Asiwe Abodunrin Adebayo Ojetola Nwoke Enekabokom Ekene Esthinsheen Osirim Anthony Chibuzor Nnamudi Benjamin Oritsemuelebi Jackson Erozueme Onuelu Nicholas Asiwe Harrison Ogheneochuko Eruotor Saviour Inegbenehi 
Objective:Myocardial infarction(MI)is linked to an imbalance in the supply and demand of blood oxygen in the heart muscles.Beta-blockers and calcium antagonists are just two of the common medications used to treat MI....
关键词：antioxidants extracellular signal-regulated kinase Ginkgo biloba extract ISOPRENALINE mammalian target of rapamycin myocardial infarction Na^(+) K^(+)-ATPase 
IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway被引量：1
《Acta Pharmacologica Sinica》2022年第10期2542-2549,共8页Shuai-xing Wang Ye-nan Feng Shan Feng Ji-min Wu Mi Zhang Wen-li Xu You-yi Zhang Hai-bo Zhu Han Xiao Er-dan Dong 
This work was supported by the National Key R&D Program(grant numbers 2020YFC2004704 to HX);Natural Science Foundation of China(grant numbers 82030072 to HX,81830009 to YYZ,and 82070235 to EDD);the Beijing Municipal Natural Science Foundation(grant number 7191013 to EDD);Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases,Chinese Academy of Medical Sciences(2021RU003 to EDD);the Key Clinical Projects of Peking University Third Hospital[BYSYZD2019022 to HX].
Upon chronic stress,β-adrenergic receptor activation induces cardiac fibrosis and leads to heart failure.The small molecule compound IMM-H007 has demonstrated protective effects in cardiovascular diseases via activat...
关键词：IMM-H007 sympathetic stress cardiac fibrosis AMP-activated protein kinase transforming growth factorβ1 
Glibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation被引量：3
《Acta Pharmacologica Sinica》2022年第5期1243-1250,共8页Ning Cao Jing-jing Wang Ji-min Wu Wen-li Xu Rui Wang Xian-da Chen Ye-nan Feng Wen-wen Cong You-yi Zhang Han Xiao Er-dan Dong 
This work was supported by the National Key R&D Program(grant number 2020YFC2004704 to Han Xiao);UMHS-PUHSC Joint Institute for Translational and Clinical Research(grant number BMU2019JI007 to You-yi Zhang);the Natural Science Foundation of China(grant numbers 81822003 and 81670205 to Han Xiao;81830009 to You-yi Zhang);the Beijing Municipal Natural Science Foundation(grant number 7191013 to Er-dan Dong);the Key Clinical Projects of Peking University Third Hospital(grant number BYSYZD2019022 to Han Xiao).
β-Adrenergic receptor(β-AR)overactivation is a major pathological factor associated with cardiac diseases and mediates cardiac inflammatory injury.Glibenclamide has shown anti-inflammatory effects in previous resear...
关键词：GLIBENCLAMIDE cardiac inflammation ISOPRENALINE sympathetic stress NLRP3 inflammasome adrenergic receptor 
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B被引量：7
《Acta Pharmaceutica Sinica B》2022年第5期2374-2390,共17页Yuhong Zhang Yanqing Ding Min Li Jing Yuan Youhui Yu Xueying Bi Huiqi Hong Jiantao Ye Peiqing Liu 
supported by grants from the National Natural Science Foundation of China (81872860,81673433,and82070268);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y093,China);National Major Special Projects for the Creation and Manufacture of New Drugs (2019ZX09301104,China);National Engineering and Technology Research Center for New drug Druggability Evaluation (Seed Program of Guangdong Province,2017B090903004,China);Special Program for Applied Science and Technology of Guangdong Province (2015B020232009,China);Guangdong Basic and Applied Basic Research Foundation(2020A1515011512,China);Young Teacher Training Program of Sun Yat-sen University (18ykpy26,China)。
Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs(miRNAs) play multiple roles in biological processes...
关键词：Pathological cardiac hypertrophy ISOPRENALINE miR-34c-5p ATG4B LC3 AUTOPHAGY Autophagic flux Neonatal rat cardiomyocytes Mice 
Different conformational responses of theβ_(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
《National Science Review》2021年第9期106-115,共10页Fan Yang Shenglong Ling Yingxin Zhou Yanan Zhang Pei Lv Sanling Liu Wei Fang Wenjing Sun Liaoyuan A.Hu Longhua Zhang Pan Shi Changlin Tian 
supported by the National Key Research and Development Project of China(2016YFA0400903 to C.L.and2017YFA0505400 to P.S.);the National Natural Science Foundation of China(21825703 to C.L.and 31971152 to P.S.);the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2018CXFX004)。
G protein-coupled receptors(GPCRs)are responsible for most cytoplasmic signaling in response to extracellular ligands with different efficacy profiles.Various spectroscopic techniques have identified that agonists exh...
关键词：cryo-EM structure G protein-coupled receptor(GPCR) partial and full agonists conformational change DESENSITIZATION 
Protective effect of different medicinal parts of Lonicera japonica Thunb. on myocardial ischemic injury induced by isoproterenol in rats
《TMR Aging》2020年第3期74-79,共6页Jia-He Wei Xia Feng Hua-Yi Liang Sheng-Bin Nong Wen Jiao Jia-Hui Gan Guang-Shun Han Chun-Jia Huang Suo-Yi Huang 
This study was supported by 2016 National College Students Innovation and Entrepreneurship Training Project(201610599001);Guangxi Key R&D Project(Gui Ke AB18221095);Youjiang Medical College for Nationalities High-level Talent Research Project(01002018079).
Background:To study the protective effect of different medicinal parts of honeysuckle on myocardial ischemia injury in rats.Method:SD mice were randomly divided into 6 groups:the normal group,model group,compound salv...
关键词：Lonicera japonica Thunb. Different medicinal parts ISOPRENALINE Ischemia myocardial Mice 
Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart F ailure Rats via Inhibiting P38 MA PK Pathway被引量：19
《Current Medical Science》2020年第2期307-312,共6页Mao LIU Jie FENG Qian DU Jiao AI Zhan LV 
This study was supported by grants from Scientific Research Development Program of North Sichuan Medical College(No.CBY16-A-ZD10);Nanchong Government-University Strategic Cooperation Project in Science and Technology(No.18SXHZ0505).
Paconiflorin(Pae)is a monoterpenoid glycoside compound and has many biological activitics,such as immunosuppression,anti-inflammation and anti-cell proliferation.However,the effects and mechanisms of Pae on chronic he...
关键词：chronic heart failure paconiflorin myocardial fibrosis P38 transforming growth factorβ1 
MicroRNA-210 Plays a Critical Role in the Angiogenic Effect of Isoprenaline on Human Umbilical Vein Endothelial Cells via Regulation of Noncoding RNAs被引量：2
《Chinese Medical Journal》2016年第22期2676-2682,共7页You-You Yan Zhi-Hui Wang Lei Zhao Dan-Dan Song Chao Qi Lu-Lu Liu Jun-Nan Wang 
This study was supported by the grants from the National Natural Science Foundation of China （No. 81470024）, and the Development and Reform Commission of Jilin Province （No. 2013C023-1）.
Background：β-adrenoceptors play a crucial regulatory role in blood vessel endothelial cells.Isoprenaline （ISO,a β-adrenergic agonist） has been reported to promote angiogenesis through upregulation of vascular end...
关键词：ANGIOGENESIS ISOPRENALINE Long Noncoding RNAs MICRORNAS 
Isoprenaline increases serum levels of monocyte chemoattractant protein-1 and tissue inhibitor of matrix metalloproteinases type I in Wistar rats
《South China Journal of Cardiology》2016年第2期110-116,共7页雷和平 张梦珍 杨翔宇 侯兴华 林秋雄 杨敏 钟诗龙 
supported by the National Natural Science Foundation of China(No.81202602/81373486)
Background Treatment of rats with the beta-adrenergic agonist Isoprenaline（ISO） results in cardiac hypertrophy and myocardial fibrosis.In the present work,we aimed to study the in vivo effects of ISO on serum levels...
关键词：monocyte TIMP hematoxylin eosin collagen hypertrophy adrenergic injected visualization stained 
Protective Effect of Catalpol on Myocardium in Rats with Isoprenaline-Induced Myocardial Infarcts via Angiogenesis through Endothelial Progenitor Cells and Notch1 Signaling Pathway被引量：2
《Pharmacology & Pharmacy》2013年第8期619-627,共9页Jing Zeng Feng Huang Yuangqing Tu Saichun Wu Manping Li Xiaoyun Tong 
Protective effect of catalpol on myocardium was studied in relation to endothelial progenitor cells, Notch1 signaling pathway and angiogenesis in rats with isoprenaline (INN)-induced acute myocardial infarcts. To anal...
关键词：Myocardial Infarction Endothelial PROGENITOR Cell NOTCH1 Signaling Pathway ANGIOGENESIS CATALPOL 
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