Pleiotropic attenuating effect of Ginkgo biloba against isoprenalineinduced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase activities  

作　　者：Jerome Ndudi Asiwe Abodunrin Adebayo Ojetola Nwoke Enekabokom Ekene Esthinsheen Osirim Anthony Chibuzor Nnamudi Benjamin Oritsemuelebi Jackson Erozueme Onuelu Nicholas Asiwe Harrison Ogheneochuko Eruotor Saviour Inegbenehi 

机构地区：[1]Department of Physiology,Delta State University,Abraka 1,Nigeria [2]Department of Physiology,University of Ibadan,Ibadan 3017,Nigeria [3]Department of Physiology,Adeleke University,Ede 250,Nigeria [4]Department of Pharmacology,Rivers State University,Nkpolu-Oroworukwo 5080,Nigeria [5]Department of Physiology,Redeemer’s University,Ede 230,Nigeria [6]Department of Biochemistry,PAMO University of Medical Sciences,Port Harcourt 500211,Nigeria [7]Department of Pharmacology,Delta State University,Abraka 1,Nigeria [8]Department of Anatomy,University of Port Harcourt,Choba 5323,Nigeria [9]Department of Medical Laboratory Sciences,University of Port Harcourt,Choba 5323,Nigeria

出　　处：《Chinese Herbal Medicines》2024年第2期282-292,共11页中草药（英文版）

摘　　要：Objective:Myocardial infarction(MI)is linked to an imbalance in the supply and demand of blood oxygen in the heart muscles.Beta-blockers and calcium antagonists are just two of the common medications used to treat MI.However,these have reportedly been shown to be either ineffective or to have undesirable side effects.Extract of Ginkgo biloba leaves(GBE),a Chinese herbal product offers special compatibility benefits in therapeutic settings relating to inflammatory diseases and oxidative stress.In order to better understand how GBE affects MI in rats insulted by isoprenaline(ISO),the current study was designed.Methods:The heart weight index,serum lipid profile,cardiac marker enzymes,endogenous antioxidants[catalase(CAT),superoxide dismutase(SOD),glutathione(GSH),nitrites and malondialdehyde(MDA)],inflammatory mediators[tumour necrosis factor alpha(TNF-a)and interleukin-6(IL-6)],immunohistochemical expressions of B-cell lymphoma factor-2(Bcl-2),extracellular signal-regulated kinase(ERK1/2),and mammalian target of rapamycin(mTOR)and histopathological analysis were used to assess the cardioprotective properties of GBE.Results:The findings showed that GBE effectively attenuated myocardial infarction by boosting the body’s natural antioxidant defense system and reducing the release of inflammatory cytokines as well as heart injury marker enzymes.The expression of Bcl-2,ERK1/2 and mTOR was increased while the histomorphological alterations were reversed.Conclusion:The cardioprotective effects of GBE may be due to a mechanism involving increased Bcl-2/mTOR/ERK1/2/Na^(+),K^(+)-ATPase activity.

关 键 词：antioxidants extracellular signal-regulated kinase Ginkgo biloba extract ISOPRENALINE mammalian target of rapamycin myocardial infarction Na^(+) K^(+)-ATPase 

分 类 号：R285[医药卫生—中药学]