GLIBENCLAMIDE

作品数：33被引量：66H指数：4
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相关领域：医药卫生更多>>
相关作者：张爱军乔善义郭继芬赵毅民更多>>
相关机构：苏州大学军事医学科学院更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Journal of Diabetes Mellitus》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金河北省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double- blind, placebo- controlled clinical trial
《Stroke & Vascular Neurology》2024年第5期530-540,共11页Xuebing Feng Tongyu Zhang Ning Wang Xin Qu Meng Qi Hao Zhao Hongqi Zhang Yueqiao Xu 
National Natural Youth Science Foundation Project(82001324).
Background Glibenclamide has garnered attention due to its multifaceted neuroprotective effects in cases of acute central nervous system injury.We initiated a trial to explore the effectiveness and safety of a high do...
关键词：EDEMA admitted protective 
Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood-brain barrier dysfunction
《Chinese Neurosurgical Journal》2024年第1期8-19,共12页Zongwei Zeng Liang Liang Zhou Feng Peiwen Guo Xiaoke Hao Jishu Xian Hua Feng Yujie Chen Zhi Chen 
supported by the National Natural Science Foundation of China(No.81771241 to Zhi Chen);Third Military Medical University(No.XZ-2019-505-002 to Zhi Chen);Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science&Technology Bureau,No.2023GGXM003 to Hua Feng)
Background Hematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently,especially in warfarin-associated intracerebral hemorrhage(W-ICH).In the present study,we employ the war...
关键词：Intracerebral hemorrhage WARFARIN GLIBENCLAMIDE Hematoma expansion Blood-brain barrier Matrix metallopeptidase-9 
Identified Analytical Profile for Microelements, Trace Metals, Amino Acids and Screening of Anti-Diabetic Activity from Flower and Leaf Extracts of Moringa oleifera in Streptozotocin (STZ)-Induced Diabetic Rats
《Pharmacology & Pharmacy》2022年第6期149-163,共15页Hemalatha Kamurthy Sirajunisa Talath 
Background: Moringa oleifera plant is popularly known for its rich phytoconstituents and nutritional value and important medicinal values in both traditional and modern systems of medicine. We explored the present stu...
关键词：Moringa oleifera MICROELEMENTS Nutritional Values Gallic Acid Amino Acids STREPTOZOTOCIN GLIBENCLAMIDE 
Antidiabetic Potential of Carthamus oxycantha M.Bieb. Seeds in Alloxan Induced Diabetic Rats
《Pharmacology & Pharmacy》2022年第6期189-198,共10页Ali Imran Abid Hira Muzammel Humera Shafi Mouqadus Un Nisa Hassan Ali Muhammad Waqar Afzal Nadeem UL Hassan Khan Fahad Muzammil 
Ethnopharmacological Relevance: Diabetes Mellitus is one of the most common disorders of metabolic abnormalities. It is characterized by hyperglycemia followed by abnormalities in insulin release, insulin work, or bot...
关键词：Diabetes Mellitus Carthamus oxycantha ALLOXAN GLIBENCLAMIDE AEECO 
Glibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation被引量：3
《Acta Pharmacologica Sinica》2022年第5期1243-1250,共8页Ning Cao Jing-jing Wang Ji-min Wu Wen-li Xu Rui Wang Xian-da Chen Ye-nan Feng Wen-wen Cong You-yi Zhang Han Xiao Er-dan Dong 
This work was supported by the National Key R&D Program(grant number 2020YFC2004704 to Han Xiao);UMHS-PUHSC Joint Institute for Translational and Clinical Research(grant number BMU2019JI007 to You-yi Zhang);the Natural Science Foundation of China(grant numbers 81822003 and 81670205 to Han Xiao;81830009 to You-yi Zhang);the Beijing Municipal Natural Science Foundation(grant number 7191013 to Er-dan Dong);the Key Clinical Projects of Peking University Third Hospital(grant number BYSYZD2019022 to Han Xiao).
β-Adrenergic receptor(β-AR)overactivation is a major pathological factor associated with cardiac diseases and mediates cardiac inflammatory injury.Glibenclamide has shown anti-inflammatory effects in previous resear...
关键词：GLIBENCLAMIDE cardiac inflammation ISOPRENALINE sympathetic stress NLRP3 inflammasome adrenergic receptor 
Synthesis,Characterization,Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acids
《Chinese Journal of Structural Chemistry》2021年第3期291-300,271,共11页HAMID Aziz AAMER Saeed FARUKH Jabeen ABDUL Basit IRFAN Zia Qureshi ABDUL Aziz ATIF Haroon ASHFAQ Ur Rehman 
Financial support of the Higher Education Commission(HEC)Pakistan,by awarding indigenous fellowship batch-1 phase-ΙΙfor M.Phil leading to Ph.D。
The present research paper presents the synthesis, characterization, biological and computational studies of 4-(benzylideneamino) benzoic acid derivatives(3a~3g). Derivatives 3a~3c displayed best antidiabetic potentia...
关键词：ANTIDIABETIC BIOCHEMICAL CHOLESTEROL GLIBENCLAMIDE simulations 
UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk,Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies
《Journal of Analysis and Testing》2020年第4期281-290,共10页Faiza Akhtar Somia Gul Salman Ashfaq Iqra Rehman Agha Zeeshan Mirza 
A simple,easy and cost-efficient UV spectroscopic method was developed and validated for glibenclamide,the second generation of sulfonylureas,using 0.1 N NaOH as a solvent.The proposed method is linear(R^(2)>0.999)wit...
关键词：GLIBENCLAMIDE INTERACTION QUINOLONES NSAIDS UV spectroscopy 
Administration of Fenugreek Seed Extract Produces Better Effects in Glibenclamide-Induced Inhibition in Hepatic Lipid Peroxidation: An in vitro Study被引量：1
《Chinese Journal of Integrative Medicine》2019年第4期278-284,共7页Sharma Neha Kar Anand Panda Sunanda 
Supported by Department of Science and Technology(DST),University Grants Commission,New Delhi,India
Objective: To evaluate the comparative effects of fenugreek(Trigonel a foenum graecum) seed extract(FSE) alone and in combination with an antidiabetic conventional medicine,glibenclamide(GLB),on the inhibition of in v...
关键词：FENUGREEK GLIBENCLAMIDE antioxidant activity lipid PEROXIDATION 
Effect of 'Double C' therapy combined with glibenclamide in the treatment of GDM patients and its influence on serum omentin-1 and VF levels
《Journal of Hainan Medical University》2019年第6期59-62,共4页Juan Li Jian Guo Chun-Xia Ren 
National Natural Science Foundation of China.Project No:81402147.
Objective: To analyze the effect of 'double C' therapy combined with glibenclamide in the treatment of GDM and its influence on serum omentin-1 and VF levels. Methods: 100 patients with GDM admitted to our hospital fr...
关键词：Bi-C THERAPY GLIBENCLAMIDE GDM OMENTIN-1 Visfatin 
Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels被引量：2
《Protein & Cell》2018年第6期553-567,共15页Jing-Xiang Wu Dian Ding Mengmeng Wang Yunlu Kang Xin Zeng Lei Chen 
The work is supported by grants from the Ministry of Science and Technology of China （National Key R＆D Program of China, 2016YFA0502004 to Lei Chen） and National Natural Science Foundation of China （Grant Nos. 31622021 and 31521062 to Lei Chen） and Young Thousand Talents Program of China to Lei Chen and the China Postdoctoral Science Foundation （2016M600856 and 2017T100014 to Jing-Xiang Wu）. Jing-Xiang Wu is supported by the postdoctoral foundation of the Peking-Tsinghua Center for Life Sci- ences, Peking University.
ATe-sensitive potassium channels （KATP） are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATe channels control insulin release and regulate metabo- lism a...
关键词：KATP SUR ABC transporter GLIBENCLAMIDE SULFONYLUREA diabetes 
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