Protective effect of different medicinal parts of Lonicera japonica Thunb. on myocardial ischemic injury induced by isoproterenol in rats  

作　　者：Jia-He Wei Xia Feng Hua-Yi Liang Sheng-Bin Nong Wen Jiao Jia-Hui Gan Guang-Shun Han Chun-Jia Huang Suo-Yi Huang 

机构地区：[1]Clinical Medical College of Youjiang Medical College for Nationalities,Guangxi Baise,533000,China [2]College of Pharmacy of Youjiang Medical College for Nationalities,Baise 533000,China [3]College of Imaging of Youjiang Medical College for Nationalities,Baise,533000,China [4]Key Laboratory of Guangxi’s Colleges for the Study of Characteristic Ethnic Medicine in Youjiang RiverBasin,Youjiang Medical College of Nationalities,Baise,533000,China

出　　处：《TMR Aging》2020年第3期74-79,共6页衰老研究

基　　金：This study was supported by 2016 National College Students Innovation and Entrepreneurship Training Project(201610599001);Guangxi Key R&D Project(Gui Ke AB18221095);Youjiang Medical College for Nationalities High-level Talent Research Project(01002018079).

摘　　要：Background:To study the protective effect of different medicinal parts of honeysuckle on myocardial ischemia injury in rats.Method:SD mice were randomly divided into 6 groups:the normal group,model group,compound salvia miltiorrhiza group,Lonicera japonica Thunb.of flower bud group,flower group,and the stem leaf group.There were 8 rats in each group,including 4 males and 4 females.The normal group and model group were given equal amount of distilled water,whereas the other dosage groups were given the appropriate drug by intragastric administration,continuous gavage for 14 days.From the 12 days,in addition to the normal group were injected of the same amount of normal saline,the other groups were injected with 5g/kg.Injection of isoproterenol to establish the mouce mycardial ischemia model,its continuously 3d.To detect the serum of AST,CK,CK-MB,LDH and the myocardial issue of Chinese super oxideismutase and malondialdehyde level.Results:Compared with normal group,the levels of AST,CK,CK-MB,cTn-I,LDH and malondialdehyde were significantly increased in the model group(P<0.01)and the level of super oxideismutase decreased significantly(P<0.01)the levels of AST,CK,CK-MB,cTn-I,LDH and malondialdehyde in the serum of flower bud group,flower group and stem leaf group were significantly decreased(P<0.05),and the decreasing level of flower bud group,flower,leaf group of AST,CK,CK-MB,cTn-I,LDH and malondialdehyde was flower bud group>flower>leaf group,the activity of super oxideismutase was obviously increased,and the activity level of super oxideismutase of flower bud group,flower group and stem leaf group was flower bud group>flower>leaf group.Conclusion:In the myocardial ischemic injury model of rats induced by isoproterenol,Lonicera japonica Thunb.had a protective effect in all parts,and Lonicera japonica Thunb.bud had the greatest protective effect.

关 键 词：Lonicera japonica Thunb. Different medicinal parts ISOPRENALINE Ischemia myocardial Mice 

分 类 号：R54[医药卫生—心血管疾病]