CATALPOL

作品数：24被引量：134H指数：7
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相关领域：医药卫生更多>>
相关期刊：《Neural Regeneration Research》《解剖学杂志》《China Medical Abstracts(Internal Medicine)》《Current Medical Science》更多>>
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Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review被引量：2
《Journal of Pharmaceutical Analysis》2023年第10期1089-1101,共13页Zixi Zhang Yongguo Dai Yichao Xiao Qiming Liu 
supported by the National Natural Science Foundation of China(Grant Nos:.82070356 and 81770337);the Key Project of Hunan Provincial Science and Technology Innovation,China(Grant No.:2020SK1013);the Hunan Provincial Natural Science Foundation of China(Grant No.:2021JJ30033).
Catalpol,an iridoid glucoside isolated from Rehmannia glutinosa,has gained attention due to its potential use in treating cardio-cerebrovascular diseases(CVDs).This extensive review delves into recent studies on catal...
关键词：CATALPOL Cardio-cerebrovascular diseases ANTI-ATHEROSCLEROSIS Cerebrovascular protection Heart protection 
Catalpol Prevents Glomerular Angiogenesis Induced by Advanced Glycation End Products via Inhibiting Galectin-3被引量：2
《Current Medical Science》2023年第4期668-678,共11页Wei-xiang SUN Yu-yan GAO Ying CAO Jin-fu LU Gao-hong LV Hui-qin XU 
supported by grants from the National Natural Science Foundation of China(No.81374029,No.81073111,No.81874359);Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.18KJD360002);a Project Funded by Jiangsu Agri-animal Husbandry Vocational College(No.NSF2021CB04);a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)(No.JKLPSE201604).
Objective:The main characteristics of diabetic nephropathy(DN)at the early stage are abnormal angiogenesis of glomerular endothelial cells(GECs)and macrophage infiltration.Galectin-3 plays a pivotal role in the pathog...
关键词：CATALPOL glomerular angiogenesis advanced glycation end products GALECTIN-3 
Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling被引量：23
《Acta Pharmacologica Sinica》2022年第7期1670-1685,共16页Hong-jin Wang Hai-feng Ran Yue Yin Xiao-gang Xu Bao-xiang Jiang Shi-qi Yu Yi-jin Chen Hui-jing Ren Shan Feng Ji-fen Zhang Yi Chen Qiang Xue Xiao-yu Xu 
This work was supported by National Natural Science Foundation of China(81473549 to XYX and 81773984 to YC);the Fundamental Research Funds for the Central Universities(XDJK2020D037 to HJW);the Chongqing Postgraduate Research Innovation Project(CYS18098 to HJW).
Neurovascular unit(NVU)is organized multi-cellular and multi-component networks that are essential for brain health and brain homeostasis maintaining.Neurovascular unit dysfunction is the central pathogenesis process ...
关键词：ischemic stroke CATALPOL neurovascular unit(NVU) VEGF PI3K/AKT MEK1/2/ERK1/2 
Traditional herbal medicine as adjunctive therapy for colorectal cancer:a scoping review
《Traditional Medicine Research》2022年第2期43-52,共10页Siti Rohani Nurumal Nur Suhada Ramli Zulkefley Mohammad Shamsul Azhar Shah 
Background:A variety of therapy options are available for colorectal cancer,ranging from traditional medicine to complementary and alternative medicine.There is a growing body of evidence supporting the efficacy of co...
关键词：traditional and herbal medicine colorectal cancer CATALPOL DAIKENCHUTO AIDI Simo decoction Goshajinkigan 
Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF-β1/TAK1 signaling pathway被引量：1
《Acta Pharmacologica Sinica》2021年第7期1080-1089,共10页Deng-qiu Xu Lei Zhao Si-jia Li Xiao-fei Huang Chun-jie Li Li-xin Sun Xi-hua Li Lu-yong Zhang Zhen-zhou Jiang 
This work was supported by grants from the Scholar of the 14th Batch of"Six Talents Peak"High-level Talent Selection Program(SWYY-094);the Postgraduate Research Practice Innovation Program of Jiangsu Province(KYCX19-0763);the"Double First-Class"University Project(CPU2018GY33);and the National Natural Science Foundation of China(Nos.81773827 and 81573514 to ZZJ,No.81773995 to LYZ).
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by a mutation in the gene encoding the dystrophin protein. Catalpol is an iridoid glycoside found in Chinese herbs with anti-inflammatory...
关键词：Duchenne muscular dystrophy CATALPOL TGF-Β1 TAK1 Α-SMA muscle fibrosis 
Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation被引量：20
《解剖学杂志》2021年第S01期125-125,共1页Wu Haoran Wang Yalim Hu Juntao 
The purpose of the present study was to investigate whether catalpol exhibited neuro-protective effects in chronic unpredictable mild stress(CUMS)mice through oxidative stress-mediated nucleotide-binding oligomerizati...
关键词：NLRP3 inflammation protective 
Current Situation of Chinese Medicine Combined with MSCs for the Treatment of the Neurovascular Unit Injury After Cerebral lschemia
《Chinese Medicine and Natural Products》2021年第1期36-47,共12页LI Mengdi ZHANG Yunke 
We thank for the funding support from the National Natural Science Foundation of China(8197151612);Henan Provincial Project of Outstanding Talents in Science and Technology Innovation(2018JR0006).
Stroke has been a common problem in the global public health because of its high incidence,recur-rence,disability rate and mortality,among which ischemic stroke accounts for about 80%of the total stroke.Cerebral ische...
关键词：neurovascular unit(NVU) MSCS Sanqi(Radix et Rhizoma Notoginseng) Huangqi(Radix Astragai) chry-sin CATALPOL COSTUNOLIDE Buy ang Huanwu Decoction 
The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis被引量：9
《Acta Pharmacologica Sinica》2020年第6期791-799,共9页Deng-qiu Xu Chun-jie Li Zhen-zhou Jiang Lu Wang Hong-fei Huang Zhi-jian Li Li-xin Sun Si-si Fan Lu-yong Zhang Tao Wang 
This work was supported by grants from the National Natural Science Foundation of China(No.81403154,81773827,81573514,81773995,81873084,81573690);the Scholar of the 14th Batch of"Six Talents Peak"High-level Talent Selection program(SWYY-094);the Postgraduate Research Practice Innovation Program of Jiangsu Province(KYCX19-0763);the"Double First-Class"University project(CPU2018GY33);the Qinghai Province High-End Innovative Thousand Talents Program;and theTianshan Cedar Project of the Xinjiang Uygur Autonomous Region(2018XS21).
Mitochondria serve as sensors of energy regulation and glucose levels,which are impaired by diabetes progression.Catalpol is an iridoid glycoside that exerts a hypoglycemic effect by improving mitochondrial function,b...
关键词：CATALPOL AMPK MITOCHONDRIA BIOGENESIS type 2 diabetes skeletal muscle 
Erratum to: Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling被引量：4
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2020年第4期341-341,共1页Hua ZHANG Zhi-min WU Ya-ping YANG Aftab SHAUKAT Jing YANG Ying-fang GUO Tao ZHANG Xin-ying ZHU Jin-xia QIU Gan-zhen DENG Dong-mei SHI 
Erratum to:J Zhejiang Univ-Sci B(Biomed&Biotechnol)201920(10):816-827 https://doi.org/10.1631/jzus.B1900071The original version of this article unfortunately contained a mistake.In p.823,Figs.8 c and 8 d were incorrec...
关键词：MISTAKE placed PICTURE 
Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th)1, Th2,Th17, and regulatory T cell responses被引量：3
《Journal of Traditional Chinese Medicine》2019年第6期809-817,共9页Wei Mingyan Yang Tao Li Qian Zhou Dongdong Du Zongpan Fan Yongping 
Supported by the National Natural Science Foundation(No.81973599);Beijing Natural Science Foundation-Key Project of Science and Technology Plan of Beijing Education Commission(KZ/KM/SZ/SM201910025035);The Fund for Beijing Science&Technology Development of Traditional Chinese Medicine(No.QN2018-30)
OBJECTIVE:To examine the effects of catalpol and rhein on pro-and anti-inflammatory responses in C57 BL/6 mice with experimental autoimmune encephalomyelitis(EAE),a model of multiple sclerosis.METHODS:Female C57 BL/6 ...
关键词：Multiple sclerosis ENCEPHALOMYELITIS AUTOIMMUNITY CATALPOL RHEIN Th1-Th2 balance Th17 cells 
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