BIOGENESIS

作品数：139被引量：528H指数：11
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相关作者：侯聪聪杨万喜姜勇麻彤辉贺敏更多>>
相关机构：中国科学院北京大学浙江大学东北师范大学更多>>
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Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice
《Science China(Life Sciences)》2025年第3期777-792,共16页Yiling Zhou Chaofeng Tu Charles Coutton Jianan Tang Shixiong Tian Shuyan Tang Guillaume Martinez Dapeng Zhou Célia Tebbakh Jiaxiong Wang Raoudha Zouari Xuehai Zhou Selima Fourati Ben Mustapha Xuemei Wang Bangguo Wu Xinyan Geng Shuang Liu Li Jin Huijuan Shi Yue-Qiu Tan Pierre FRay Lingbo Wang Xiaoyu Yang Feng Zhang Chunyu Liu 
supported by the National Natural Science Foundation of China(32288101,32100480,32370654,82271638,32322017);the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);Shanghai Hospital Development Center Foundation(SHDC12023121);the outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China(2023JJ20080).
Asthenoteratozoospermia is a common cause of male infertility.To further define the genetic causes underlying asthenoteratozoospermia,we performed whole-exome sequencing in a cohort of Han Chinese men with asthenotera...
关键词：male infertility asthenoteratozoospermia MYCBPAP acrosome biogenesis MANCHETTE AXONEME 
Lipid droplets in the nervous system:involvement in cell metabolic homeostasis
《Neural Regeneration Research》2025年第3期740-750,共11页Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang 
funded by Basic Research Program of Shanghai,No.20JC1412200(to JW);the National Key Research and Development Program of China,No.2020YFA0113000(to RCZ)。
Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous system.Lipid droplet formation begins with the synthesis of neutral lipids in the endoplasmic...
关键词：Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease 
Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress
《World Journal of Diabetes》2025年第2期133-150,共18页Chong-Xi Yuan Xuan Wang Yun Liu Tian-Cheng Xu Zhi Yu Bin Xu 
National Natural Science Foundation of China,No.82074532,No.82374577,No.82305375,No.82305376,and No.82405567;The Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
BACKGROUND Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities.The effects mediated by the silent i...
关键词：ELECTROACUPUNCTURE Type 2 diabetic peripheral neuropathy Silent matching type information regulation 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1αaxis Mitochondria biogenesis Oxidative stress 
Unraveling the RNA code:a uridine RNA modification drives glycoRNA biogenesis
《Signal Transduction and Targeted Therapy》2024年第12期5377-5378,共2页Marco Sachse Konstantinos Stellos 
supported by a physician scientist programme fellowship from the Helmholtz Institute for Translational AngioCardioScience(HI-TAC);supported by grants from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(MODVASC,grant agreement No 759248);the German Research Foundation DFG(CRC1366 C07,project number 394046768);the Health+Life Science Alliance Heidelberg Mannheim GmbH and the Helmholtz Institute for Translational AngioCardioScience(HI-TAC).
In a recent Cell study,Xie et al.1 introduce a novel mass spectrometry-based methodology for the sensitive detection and enrichment of native sialic acid-containing glycoRNA on cell surfaces.This work represents a sig...
关键词：al. glyco rid 
Unique biogenesis and kinetics of hornwort Rubiscos revealed by synthetic biology systems
《Molecular Plant》2024年第12期1833-1849,共17页Zhen Guo Oh Tanner Ashton Robison Dan Hong Loh Warren Shou Leong Ang Jediael Zheng Ying Ng Fay-Wei Li Laura Helen Gunn 
National Science Foundation grant no.MCB-2213840 to L.H.G.and MCB-2213841 to F.-W.L.
Hornworts are the only land plants that employ a pyrenoid to optimize Rubisco’s CO_(2) fixation,yet hornwort Rubisco remains poorly characterized.Here we assembled the hornwort Anthoceros agrestis Rubisco(AaRubisco)u...
关键词：HORNWORTS CO_(2) fixation RUBISCO synthetic biology structural biology assembly factors 
CCDC181 is required for sperm flagellum biogenesis and male fertility in mice
《Zoological Research》2024年第5期1061-1072,共12页Xiang-Jun Zhang Xiao-Ning Hou Jian-Teng Zhou Bao-Lu Shi Jing-Wei Ye Meng-Lei Yang Xiao-Hua Jiang Bo Xu Li-Min Wu Qing-Hua Shi 
supported by the National Natural Science Foundation of China(82071709,81971446,82171599,82374212);Global Select Project(DJK-LX-2022010)of the Institute of Health and Medicine,Hefei Comprehensive National Science Center;Joint Fund for New Medicine of USTC(YD9100002034)。
The structural integrity of the sperm flagellum is essential for proper sperm function.Flagellar defects can result in male infertility,yet the precise mechanisms underlying this relationship are not fully understood....
关键词：Male infertility CCDC181 MMAF SPERMIOGENESIS Flagellum biogenesis 
Biogenesis of Rab14-positive Endosome Buds at Golgi-endosome Contacts by the RhoBTB3-SHIP164-Vps26B Complex
《Current Medical Science》2024年第4期864-866,共3页Jing-ru WANG Jun-yao ZHANG Wei-Ke JI 
As one of the basic processes of cellular activity,endocytosis sorting determines the fate of many proteins on the endosomal membranes,thus affecting a variety of important cellular processes,such as nutrient uptake,c...
关键词：HOMEOSTASIS ENDO sorting 
Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers
《Genes & Diseases》2024年第2期597-613,共17页Yu Zhang Xinliang Gu Yang Li Yuejiao Huang Shaoqing Ju 
supported by grants from the National Natural Science Foundation of China(No.81871720,82072363);the Nantong Municipal Health Commission,Jiangsu,China(No.QA2020027).
With the development of sequencing technology,transfer RNA(tRNA)-derived small RNAs(tsRNAs)have received extensive attention as a new type of small noncoding RNAs.Based on the differences in the cleavage sites of nucl...
关键词：BIOGENESIS Biological function CANCER Mechanism Therapeutic strategy tsRNAs 
Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice被引量：2
《Journal of Genetics and Genomics》2024年第4期407-418,共12页Yaling Wang Xueying Huang Guoying Sun Jingwen Chen Bangguo Wu Jiahui Luo Shuyan Tang Peng Dai Feng Zhang Jinsong Li Lingbo Wang 
supported by the National Key Research and Development Program of China(2021YFC2701400);in part by the National Natural Science Foundation of China(32000393 and 32288101).
During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful fertilization.Severe deformities in flagella caus...
关键词：Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) INFERTILITY Sperm motility Asthenoteratozoospermia Disease modeling 
Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification
《Translational Neurodegeneration》2024年第1期259-280,共22页Chenghuan Song Wanying Huang Pingao Zhang Jiyun Shi Ting Yu Jing Wang Yongbo Hu Lanxue Zhao Rui Zhang Gang Wang Yongfang Zhang Hongzhuan Chen Hao Wang 
supported by grants from the National Natural Science Foundation of China(81973297 for HW,82073836 for HZC,and 82204374 for CHS);China Postdoctoral Science Foundation(2022M722140 for CHS);NATCM’s Project of High-level Construction of Key TCM Disciplines(zyyzdxk-2023070 for HW);Shanghai Jiao Tong University Trans-med Awards Research(STAR project 20230101 for HW).
Background Lysosomal homeostasis and functions are essential for the survival of neural cells.Impaired lysosomal biogenesis and acidification in Alzheimer’s disease(AD)pathogenesis leads to proteolytic dysfunction an...
关键词：ROCK1 Lysosomal biogenesis Lysosomal acidification TFEB Alzheimer’s disease 
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