tRNA-derived small RNAs in digestive tract diseases:Progress and perspectives  

作　　者：Mingrui Liu Xiaojun Zhuang Haiqing Zhang Weidong Ji Gang Yuan 

机构地区：[1]Center for Translational Medicine,The First Affiliated Hospital,Sun Yat-sen University Guangzhou,Guangdong 510080,China [2]School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou,Guangdong 510006,China [3]Department of Geriatrics,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510080,China [4]Department of Gastroenterology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China [5]International Medical Center,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510080,China [6]Phase I Clinical Trial Center,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510080,China

出　　处：《Genes & Diseases》2025年第3期253-264,共12页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.82073047,82272995);Guangdong Provincial Basic and Applied Basic Research Foundation Natural Science Foundation(China)(No.2022A1515010954).

摘　　要：tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs that are producedthrough the precise cleavage of tRNA molecules under specific conditions. tsRNA has multiplefunctions, including inhibiting translation, acting in association with classical small RNAeffector mechanisms, or acting in conjunction with Argonaute proteins that affect cell proliferation, migration, cycle, and apoptosis. Recent studies have revealed the clinical potential oftsRNAs in numerous diseases. This article aims to provide a comprehensive and up-to-date review of the classification and biological function of tsRNAs in gastrointestinal diseases.Furthermore, this review explores the underlying mechanisms by which tsRNAs are believedto exert their effects in both tumor and non-tumor digestive tract diseases. Therefore, specifictsRNAs prove promising for disease diagnosis, prognosis prediction, and therapeutic interventions as novel biomarkers for digestive tract diseases.

关 键 词：BIOGENESIS Biological function Digestive tract diseases Mechanism tRNA-derived small RNAs(tsRNAs) 

分 类 号：R57[医药卫生—消化系统]