supported by the National Science Fund for Distinguished Young Scholars of China (No.81925015);the National Natural Science Foundation of China (No.91649202);the Shandong Provincial Key Research&Development Program (China) (No.2018YFJH0504);the open fund of the State Key Laboratory of Reproductive Medicine (China) (SKLRM-K202201).
Infertility affects around 8%-12%of couples globally,and in about 50%of these cases,male factors are either the primary cause or contribute significantly to infertility.Any defects during spermiogenesis may result in ...
This work was supported by the grants from the STI 2030-Major Projects(Nos.2021ZD0204500,and 2021ZD0204503 to L.L.);the National Natural Science Foundation of China(No.32171461 to H.H.);the Scientific Research Instrument and Equipment Development Project of the Chinese Academy of Sciences(No.YJKYYQ20210022 to H.H.).
Three-dimensional(3D)reconstruction serves as a crucial instrument for the analysis of biological structures.In particular,a comprehensive and accurate 3D ultrastructural examination of rat sperm is vital for understa...
supported by National Natural Science Foundation of China(32270807 and 31900538);Shandong Natural Science Foundation(2022HWYQ-075 and tsqn202211109)。
Cilia are hair-like cellular projections essential for development and homeostasis,which can be grouped into either immotile or motile cilia based on their motility.In vertebrates,motile cilia that line the brain vent...
supported by the National Natural Science Foundation of China(82071709,81971446,82171599,82374212);Global Select Project(DJK-LX-2022010)of the Institute of Health and Medicine,Hefei Comprehensive National Science Center;Joint Fund for New Medicine of USTC(YD9100002034)。
The structural integrity of the sperm flagellum is essential for proper sperm function.Flagellar defects can result in male infertility,yet the precise mechanisms underlying this relationship are not fully understood....
supported by grants from the National Natural Science Foundation of China(Grant No.31890784 to J.S.);National Key R&D Program(Grant No.2021YFC2700200 to X.G.);National Natural Science Foundation of China(Grant Nos.92068109 and 82122025 to Yan Yuan);Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.21KJA310007 to Yan Yuan);Science Foundation of Gusu School(Grant No.GSKY20220101 to J.S.).
Peroxisomes are organelles enclosed by a single membrane and are present in various species.The abruption of peroxisomes is correlated with peroxisome biogenesis disorders and single peroxisomal enzyme deficiencies th...
the Ningbo Science and Technology Plan Projects(Nos.2019B10016,2016C10004);the Major Science and Technology Projects in Zhejiang Province(No.2011C12013);the Natural Science Foundation of Zhejiang Province(No.LY18C190007);the Collaborative Innovation Center for Zhejiang Marine High-efficiency and Healthy Aquaculture,the K.C.Wong Magna Fund in Ningbo University。
Mitochondria undergo morphological changes during spermatogenesis in some animals.The mechanism and role of mitochondrial morphology regulation,however,remain somewhat unclear.In this study,we analyzed the molecular c...
Eucaryotic cells spatially organize their molecules to form various organelles by compartmentalization, thereby performing fundamental biological process. While some of those organelles are delimited by lipid membrane...
supported by the National Natural Science Foundation of China(Grant No.31872551);Laboratory of Lingnan Modern Agriculture Project(Grant No.NT2021008);the Natural Science Foundation of Hunan Province for Distinguished Young Scholars(Grant No.2020JJ2022);Hunan Provincial Innovation Foundation for Postgraduate(Grant No.CX20200480);the earmarked fund for China Agriculture Research System(Grant No.CARS-45);the Key Research and Development Program of Hunan Province(Grant No.2020NK2016);111 Project(D20007).
Background:Sperm abnormalities are one of the primary factors leading to male sterility,but their pathogenesis is still unclear.Although miRNAs are suggested to exert important roles in the regulation of spermatogenes...
supported by the Ningbo Science and Technology Plan Projects (Nos. 2019B10016, 2016C 10004);the Major Science and Technology Projects in Zhejiang Province (No. 2011C12013);the Natural Science Foundation of Zhejiang Province (No. LY18C190007);the National Natural Science Foundation of China (No. 312 72642);the Collaborative Innovation Center for Marine High-efficiency and Healthy Aquaculture of Zhejiang Province, and K.C.Wong Magna Fund in Ningbo University
The microtubule(MT)-associated proteins KIF3A and KIF3B are ubiquitously expressed in a wide range of taxa.This study investigated the functions of these proteins in spermiogenesis,which involves various MT-dependent ...
Supported by the NSFC-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(No.U1809212);the Scientific and Technical Project of Zhejiang Province(Nos.2021C02055,2017C02013);the National Natural Science Foundation of China(No.31272642);the Healthy Aquaculture,the K.C.Wong Magna Fund in Ningbo University,and the Collaborative Innovation Center for Zhejiang Marine High-efficiency。
The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA an...