Supported by the Shenzhen University Teaching Reform Fund,No.JG2023166;the Shenzhen Science and Technology Innovation Commission Fund,No.JCYJ2022081802810022;the Shenzhen Science and Technology Innovation Commission Basic Research Key Projects Fund,No.JCYJ20210324115800003.
BACKGROUND Cases of myelin oligodendrocyte glycoprotein(MOG)antibody-related disease have a history of coronavirus disease 2019 infection or its vaccination before disease onset.Severe acute respiratory syndrome virus...
Background Rabies continues to pose significant public health challenges in many developing countries including Bhutan.A probable case of rabies was admitted to our hospital and its reporting led to the uncovering of ...
National Natural Science Foundation of China:Role and Mechanism of Akkermansia-Mediated Activation of Microglia NLRP3 Inflammasome in Multiple Sclerosis(No.82101419);Jiangxi Provincial Natural Science Foundation:the Role and Mechanism of p38 MAPK Signaling Pathway Induced by Intestinal Flora Change in EAE Mice(No.20212BAB216024);Jiangxi Science and Technology Project of Chinese Medicine:Study on the Role and Mechanism of CGAS-STING Signaling Pathway in Microglia Mediated by Rhodiola Sachalinensis in Multiple Sclerosis(No.2021B660,No.2022B1007);Jiangxi Science and Technology Program of Health Commission:the Role and Mechanism of Intestinal Flora Changes in Mediating the Activation of NLRP3 Inflammasome in Microglia in Multiple Sclerosis(No.202210392);Science and Technology Research Project of Jiangxi Education:Study on the Role and Mechanism of p38 MAPK Signaling Pathway Induced by Intestinal Flora Changes in EAE Mice(No.GJJ200215);Scientific Research and Development Project of the First Affiliated Hospital of Nanchang University:Effects of Exercise Training on Intestinal Flora of Multiple Sclerosis Model Rats and Its Mechanism(No.YFYPY202021)。
OBJECTIVE:To learn the mechanisms between gut microbiome and the autoimmunity benefits on Traditional Chinese Medicine(TCM)in central nervous system(CNS),we investigated the neuro-protection effects and gut mircobiota...
This work was supported by the National Natural Science Foundation of China(81773931 and 81374004);as well as the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support“YangFan”Project(ZYLX201802).
Dear editor,Herpes B virus(BV),also known as Macacine herpesvirus 1(family:Herpesviridae,subfamily:Alphaherpesvirinae,genus:Simplexvirus),officially designated by the International Committee on the Taxonomy of Viruses...
Objective:To investigate theanti apoptosis effect of curcumin(cur)in experimental autoimmune encephalomyelitis(EAE)mice by regulating TLRs/NF-κB signaling pathway and its mechanism.Methods:45 C57BL/6 mice were random...
supported by the National Natural Science Foundation of Shandong,China(ZR2019PH040);the National Natural Science Foundation of China(81901321).
Picornaviridae are a family of small positive-strand RNA viruses,and transmitted via the respiratory or fecal-oral route.The neurotropic picornaviruses can induce acute or late recurrent seizures following central ner...
supported by Sao Paulo Research Foundation(FAPESP,grant Nos.2015/03965-2 and 2014/00239-6);the National Council for Scientific and Technological Development(CNPq,grant Nos.307603/2018-0 and 307269/2017-5);Coordination for the Improvement of Higher Education Personnel(CAPES,Finance Code 001)。
Mast cells are immune cells of the myeloid lineage that are found throughout the body,including the central nervous system.They perform many functions associated with innate and specific immunity,angiogenesis,and vasc...
Multiple sclerosis(MS)is an inflammatory demyelinating disease of the central nervous system.The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is r...
Supported by the National Natural Science Foundation(No.81973599);Beijing Natural Science Foundation-Key Project of Science and Technology Plan of Beijing Education Commission(KZ/KM/SZ/SM201910025035);The Fund for Beijing Science&Technology Development of Traditional Chinese Medicine(No.QN2018-30)
OBJECTIVE:To examine the effects of catalpol and rhein on pro-and anti-inflammatory responses in C57 BL/6 mice with experimental autoimmune encephalomyelitis(EAE),a model of multiple sclerosis.METHODS:Female C57 BL/6 ...
This work is supported by the grants from the Natural Science Foundation of Hunan Province,China(No.2018JJ6043);the Health and Family Plans commission of Hunan Province,China(No.B20180815);the Science and Technology Plan Project of Zhuzhou City,Hunan Province,China(No.20160104).
Background:The pathogenesis of multiple sclerosis(MS)is mediated primarily by T cells,but most studies of MS and its animal model,experimental autoimmune encephalomyelitis(EAE),have focused on CD4^+ T cells.The aims o...