The role of picornavirus infection in epileptogenesis  

作　　者：Runxuan Zhang Jie Mu Jing Chi Weijia Jiang Xiaosa Chi 

机构地区：[1]West China School of Basic Medical Sciences&Fornsic Medicine,Sichuan University,Chengdu 610041,China [2]Department of Neurology,West China Hospital of Sichuan University,Chengdu 610041,China [3]School of Nursing,The South Medical University,Guangzhou 510515,China [4]West China Medical Publishers,West China Hospital of Sichuan University,Chengdu 610041,China [5]Department of Geriatrics,Affiliated Hospital of Qingdao University,Qingdao 266000,China

出　　处：《Acta Epileptologica》2021年第1期37-43,共7页癫痫学报（英文）

基　　金：supported by the National Natural Science Foundation of Shandong,China(ZR2019PH040);the National Natural Science Foundation of China(81901321).

摘　　要：Picornaviridae are a family of small positive-strand RNA viruses,and transmitted via the respiratory or fecal-oral route.The neurotropic picornaviruses can induce acute or late recurrent seizures following central nervous system infection,by infecting the peripheral nerve,crossing the blood-brain barrier and migrating in the Trojan-horse method.Theiler’s murine encephalomyelitis virus(TMEV),as a member of Picornaviridae family,can cause encephalitis,leading to chronic spontaneous seizures.TMEV-infected C57BL/6 mice have been used as an animal model for exploring the mechanism of epileptogenesis and assessing new antiepileptic drugs.Astrogliosis,neuronal death and microglial recruitment have been detected in the hippocampus following the picornaviruse-induced encephalitis.The macrophages,monocytes,neutrophils,as well as IL-6 and TNF-αreleased by them,play an important role in the epileptogenesis.In this review,we summarize the clinical characteristics of picornavirus infection,and the immunopathology involved in the TMEV-induced epilepsy.

关 键 词：Picornaviridae infection Theiler’s murine encephalomyelitis virus SEIZURE Immune response 

分 类 号：R73[医药卫生—肿瘤]