Should mast cells be considered therapeutic targets in multiple sclerosis?  

作　　者：Karen Henriette Pinke Sofia Fernanda Goncalves Zorzella-Pezavento Vanessa Soares Lara Alexandrina Sartori 

机构地区：[1]Institute of Biosciences,Department of Microbiology and Immunology,Sao Paulo State University(UNESP),Botucatu,Sao Paulo,Brazil [2]Bauru School of Dentistry,Department of Surgery,Stomatology,Pathology and Radiology,University of Sao Paulo,Bauru,Sao Paulo,Brazil

出　　处：《Neural Regeneration Research》2020年第11期1995-2007,共13页中国神经再生研究（英文版）

基　　金：supported by Sao Paulo Research Foundation(FAPESP,grant Nos.2015/03965-2 and 2014/00239-6);the National Council for Scientific and Technological Development(CNPq,grant Nos.307603/2018-0 and 307269/2017-5);Coordination for the Improvement of Higher Education Personnel(CAPES,Finance Code 001)。

摘　　要：Mast cells are immune cells of the myeloid lineage that are found throughout the body,including the central nervous system.They perform many functions associated with innate and specific immunity,angiogenesis,and vascular homeostasis.Moreover,they have been implicated in a series of pathologies(e.g.,hypersensitivity reactions,tumors,and inflammatory disorders).In this review,we propose that this cell could be a relevant therapeutic target in multiple sclerosis,which is a central nervous system degenerative disease.To support this proposition,we describe the general biological properties of mast cells,their contribution to innate and specific immunity,and the participation of mast cells in the various stages of multiple sclerosis and experimental autoimmune encephalomyelitis development.The final part of this review is dedicated to an overview of the available mast cells immunomodulatory drugs and their activity on multiple sclerosis and experimental autoimmune encephalomyelitis,including our own experience related to the effect of ketotifen fumarate on experimental autoimmune encephalomyelitis evolution.

关 键 词：central nervous system degenerative DISEASE experimental autoimmune ENCEPHALOMYELITIS immunity IMMUNOMODULATORY drugs inflammatory DISEASE KETOTIFEN FUMARATE mast cells multiple sclerosis therapeutic target 

分 类 号：R744.51[医药卫生—神经病学与精神病学]