COSTUNOLIDE

作品数：7被引量：18H指数：2
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相关领域：医药卫生更多>>
相关作者：李亮刘站柱更多>>
相关机构：东北师范大学中国医学科学院北京协和医学院更多>>
相关期刊：《Chinese Journal of Chemistry》《Acta Pharmacologica Sinica》《Chinese Medicine and Natural Products》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金更多>>
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Allosteric regulation of Keap1 by 8β-hydroxy-acyclocostunolide for the treatment of acute lung injury
《Acta Pharmaceutica Sinica B》2024年第9期4174-4178,共5页Juan Zhang Min Zhang Qi-Meng Zhu Xin-Rong Xu Yan-Li Feng Sheng Lin Feng Qiu Cheng-Peng Sun 
National Natural Science Foundation of China(No.82274069,82030116,and 82141212);China Postdoctoral Science Foundation(No.2022M720095 and 2023T160434);Young Elite Scientists Sponsorship Programby China Association of Chinese Medicine(No.2022-QNRC2-B09).
To the Editor:Acute lung injury(ALI)is a debilitating lung disease characterized by pulmonary edema,diffuse alveolar damage,and uncontrolled neutrophil infiltration^(1).Severe cases of ALI can potentially lead to the ...
关键词：Macrophage overactivation KEAP1 8β-Hydroxy-a-cyclocostunolide Nrf2 Acute lung injury 
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases被引量：9
《Acta Pharmaceutica Sinica B》2023年第2期678-693,共16页Haowen Xu Jiahao Chen Pan Chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng Chen Wu Luo Guang Liang 
supported by the National Natural Science Foundation of China(81930108 to Guang Liang,82000793 to Wu Luo,and 82170373 to Yi Wang);Natural Science Foundation of Zhejiang Province(LY22H070004 to Wu Luo,China);Zhejiang Provincial Key Scientific Project(2021C03041 to Guang Liang,China);Wenzhou Scientific Project in China(Y20210213 to Wu Luo)。
The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussu...
关键词：COSTUNOLIDE NLRP3 inflammasome Inflammation Molecular target NACHT domain α-Methylene-γ-butyrolactone Gouty arthritis Ulcerative colitis 
Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE^(−/−) mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation
《Acta Pharmacologica Sinica》2023年第1期58-70,共13页Zhu-qi Huang Wu Luo Wei-xin Li Pan Chen Zhe Wang Rui-je Chen Yi Wang Weijian Huang Guang Liang 
This study was supported by National Natural Science Foundation of China (21961142009 to GL,82000793 to WL,81900331 to ZW);Zhejiang Provincial Key Scientific Project (2021C03041 to GL).
Costunolide(CTD)is a sesquiterpene lactone isolated from costus root and exhibits various biological activities including anti-inflammation.Since atherosclerosis is a chronic inflammatory disease,we herein investigate...
关键词：ATHEROSCLEROSIS COSTUNOLIDE INFLAMMATION IKK NF-ΚB IKKΒ 
Current Situation of Chinese Medicine Combined with MSCs for the Treatment of the Neurovascular Unit Injury After Cerebral lschemia
《Chinese Medicine and Natural Products》2021年第1期36-47,共12页LI Mengdi ZHANG Yunke 
We thank for the funding support from the National Natural Science Foundation of China(8197151612);Henan Provincial Project of Outstanding Talents in Science and Technology Innovation(2018JR0006).
Stroke has been a common problem in the global public health because of its high incidence,recur-rence,disability rate and mortality,among which ischemic stroke accounts for about 80%of the total stroke.Cerebral ische...
关键词：neurovascular unit(NVU) MSCS Sanqi(Radix et Rhizoma Notoginseng) Huangqi(Radix Astragai) chry-sin CATALPOL COSTUNOLIDE Buy ang Huanwu Decoction 
Protective effects of costunolide on mouse brain slice injury induced by oxygen glucose deprivation/reoxygenation
《中国药理学与毒理学杂志》2019年第9期693-693,共1页MA Hui-xia HOU Fan CHEN Ai-ling ZHANG Zhuan-zhuan ZHU Ya-fei ZHAO Qi-peng 
National Natural Science Foundation of China(81660700;81260679);Ningxia College FirstClass Discipline Construction Project(Chinese Medicine)Funded Project(NXYLXK2017A06)
OBJECTIVE To investigate the protective effects and mechanisms of costunolide against mousebrain slice injury induced by oxygen-glucose deprivation/reoxygenation(OGD/R).METHODS Mouse brain slice injury was induced by ...
关键词：COSTUNOLIDE ischemic stroke brain slice APOPTOSIS 
Costunolide alleviates HKSA-induced acute lung injury via inhibition of macrophage activation被引量：7
《Acta Pharmacologica Sinica》2019年第8期1040-1048,共9页Yun-tian Chen Yao Du Bo Zhao Li-xing Gan Kai-kai Yu Lei Sun Jian Wang Feng Qian 
supported by the National Key Research and Development Program of China (2017YFC0908500);National Natural Science Foundation of China (81773741,81573438,31741038,and 31770921)
Staphylococcus aureus (S. aureus) infection leads to a severe inflammatory response and causes acute lung injury (ALI), eventually threatening human life. Therefore, it is of importance to find an agent to inhibit inf...
关键词：COSTUNOLIDE STAPHYLOCOCCUS AUREUS PNEUMONIA MACROPHAGE MAPK signaling 
Rapid Determination of Costunolide and Dehydrocostuslactone in Human Plasma Sample and Chinese Patent Medicine Xiang Sha Yang Wei Capsule Using HPLC-DAD Coupled with Second-order Calibration被引量：2
《Chinese Journal of Chemistry》2012年第5期1137-1143,共7页刘亚娟 吴海龙 朱绍华 康超 许慧 苏志义 谷惠文 俞汝勤 
A novel methodology that combines high performance liquid chromatography with photodiode-array detector （HPLC-DAD） coupled with second-order calibration method based on alternating trilinear decomposition （ATLD） a...
关键词：COSTUNOLIDE dehydrocostuslactone HPLC-DAD second-order calibration alternating trilinear decomposition 
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