Current Situation of Chinese Medicine Combined with MSCs for the Treatment of the Neurovascular Unit Injury After Cerebral lschemia  

中医药联合骨髓间充质干细胞治疗脑缺血后神经血管单元损伤现状

作　　者：LI Mengdi ZHANG Yunke 李梦頔;张运克(河南中医药大学第一临床医学院,郑州450046;河南中医药大学康复医学院,郑州450046)

机构地区：[1]The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China [2]School of Rehabilitation on Science,Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China

出　　处：《Chinese Medicine and Natural Products》2021年第1期36-47,共12页中医学报（英文）

基　　金：We thank for the funding support from the National Natural Science Foundation of China(8197151612);Henan Provincial Project of Outstanding Talents in Science and Technology Innovation(2018JR0006).

摘　　要：Stroke has been a common problem in the global public health because of its high incidence,recur-rence,disability rate and mortality,among which ischemic stroke accounts for about 80%of the total stroke.Cerebral ischemia reperfusion injury(CIRI)is one of the most important pathological injuries after ischemic stroke,and the effective treatment has always been a research focus at home and abroad.The proposal of the concept of neurovascular unit(NVU)which extends treatment ideas from local to holistic is in accordance with the holistic concept and treatment based on syndrome differentiation in Chinese medicine.Chinese medicine has many advantages,such as being multicomponent,multitarget,and multipath while stem cells are effective biological therapeutic means,both of which have been proved to exert comprehensive and definite effects on NVU injury caused by CIRI.This artide reviews the molecular mechanisms of NVU injury and the cerebropro-tective effects of Chinese medicine monomers or compound formulas combined with MSCs on NUV injury after cerebral ischemia,with a view to provide a theoretical basis for future studies.脑卒中因其发病率、复发率、致残率和死亡率高而成为全球公共卫生领域共同面对的难题。缺血性卒中占脑卒中的80%左右。缺血再灌注损伤是缺血性脑卒中后最重要的病理损伤之一,寻找有效的治疗方法一直是国内外研究热点。神经血管单元NVU)概念的提出,将治疗思路从局部拓展到整体,符合中医学整体观念和辨证论治的思想。中医药具有多组分、多靶点、多途径等优势,而干细胞作为有效的生物治疗手段,两者单独使用均被证实对CIRI引起的NVU损伤具有全面而确切的疗效,联合使用疗效更加显著。本文综述了脑缺血后NVU损伤的分子机制以及中药单体或复方制剂联合MSCs对脑缺血后NUV损伤的保护作用,以期为今后的研究提供理论依据。

关 键 词：neurovascular unit(NVU) MSCS Sanqi(Radix et Rhizoma Notoginseng) Huangqi(Radix Astragai) chry-sin CATALPOL COSTUNOLIDE Buy ang Huanwu Decoction 

分 类 号：R74[医药卫生—神经病学与精神病学]