米非司酮对子宫肌瘤及内膜超微结构的影响  

The effect of mifepristone on uftrastmcture of uterine leiomyoman and endometrium

作　　者：毕蕙[1] 董颍[2] 李克敏[1] 王素霞[3] 汤秀英[3] 石雪君[2] 

机构地区：[1]北京大学第一医院妇产科,100034 [2]北京大学第一医院病理科,100034 [3]北京大学第一医院电镜室,100034

出　　处：《中国妇产科临床杂志》2000年第4期201-202,257,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的 探讨米非司酮缩小子宫肌瘤及导致闭经的机制。方法 随机选择有症状的子宫肌瘤患者21例,每日服用米非司酮10 mg,连续 3个月后行子宫全切术,取子宫标本在光镜及电镜下观察子宫肌瘤及内膜组织的变化,并随机选择同期未用药的生育年龄及绝经后的肌瘤标本26例作为对照组进行比较。结果 米非司酮能抑制子宫肌瘤细胞的生长,并使子宫内膜退行性变。结论 米非司酮可用于治疗子宫肌瘤。Objective To study the mechanism of Mifepristone on inhibiting the growth of leiomyoma and inducing ame-norrhea. Methods To examine the pathologic effect of Mifepristone on uterine leiomyoma and endometrium. Mifepristone 10 mg/d for 3 months was given each of the 21 padents with symptomatic uterine leiomyoma and total hysterectomy was done 3 months later. Tile changes of leiomyoma and endometrium after hysterectomy were examined by light microscope and electron microscope. 26 patients who were before or after menopause and had uterine leiomyomas administrated at the same period for comparison. Results We found that Mifepristone could inhibit the growth of leiomyoma and degenerate the endometrium. Conclusions Leimyoma can be treated with Mifepristone.

关 键 词：子宫肌瘤 米非司酮 子宫内膜 肌瘤变性 有丝分裂相 

分 类 号：R737.33[医药卫生—肿瘤]