丙氨瑞林和达那唑治疗子宫内膜异位症对照研究  

An Randomized Comparative Study of The Effect of Alarelin and Danazol on Endometriosis

作　　者：邱晓燕[1] 酆豫增[1] 陈淑影[1] 

机构地区：[1]上海市第一人民医院妇产科

出　　处：《复旦学报（医学版）》1999年第S1期41-43,共3页Fudan University Journal of Medical Sciences

摘　　要：评价丙氨瑞林治疗子宫内膜异位症的效果和安全性。方法２２例经腹腔镜诊断为子宫内膜异位症患者随机分成２组，治疗组１４例给予丙氨瑞林１５０μｇ／ｄ，对照组８例给予达那唑４００ｍｇ／ｄ。用药共１２周，并定期随访３年。结果丙氨瑞林治疗期间痛经和下腹痛均明显缓解，盆腔肿块明显缩小占６６．７％（６／９），丙氨瑞林总有效率为７６．９％（１０／１３），无明显副作用。停药后受孕率为３０．８％（４／１３），３年内病情进展占４６．２％（６／１３），进行手术治疗占３０．８％。结论丙氨瑞林治疗子宫内膜异位症安全有效，是达那唑的有效替代药物。Purpose To evaluate the safety and efficacy of the GnRH agonist alarelin on endometriosis. Methods 22 endometriosis patients were diagnosed by laparoscopy were randomized divided into two groups.Alarelin 150 μg/d was given to 14 women(study group)and danazol 400 mg/d was administrated to 8 patients(controlled group).All patients were treated for 12 week and followed up for three years.Results All patients were accompanied by alleviation of dysmenorrhea and abdominal pain,66.7%(6/9)of endometriotic cyst in the pelvis regressed or disappeared.The effect rate of alarelin was 76.9%(10/13),and it did not have apparent side effect.After withdrawal alarelin,30.8%(4/13)of the women were pregnant,46.2%(6/13)of the women with subsequent development of endometriosis,and 30.8%(4/13)were performed surgical treatment. Conclusions Alarelin is a new drug with high effectiveness and safety for endometriosis,as marked as danazol.

关 键 词：丙氨瑞林 达那唑 子宫内膜异位症 

分 类 号：R[医药卫生]