Comparative effects of lovastatin and L-arginine on endothelium-dependent vasodilation and atherosclerosis in hypercholesterolemic rabbit  

作　　者：张金盈 董建增 李凌 赵洛沙 黄振文 魏经汉 刘瑞云 

出　　处：《Chinese Medical Journal》1999年第2期92-92,共1页中华医学杂志（英文版）

摘　　要：Objectives To investigate whether lovastatin improves endothelium dependent relaxation and decreases atherosclerosis in hypercholesterolemic animals, as compared with L arginine. Methods Forty male rabbits, randomized into four groups with ten in each group, were fed with one of the following diets: ① normal rabbit chow; ② 1% cholesterol diet; ③ 1% cholesterol diet supplemented with 2.25 g/kg L arginine soluble in the physiological salt solution (PPS) by gavage; ④ 1% cholesterol diet supplemented with 10 mg/kg lovastatin soluble in the PSS by gavage. The rabbits were fed with these diets for 10 weeks, and blood samples were collected from animals for biochemical studies. Then aortic rings were obtained, and changes in isometric tension were recorded. Intimal atherosclerotic areas of the aortae were subsequently measured by planimetry. Results Serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL C) levels were lower￣ ed (30%±6%, 39%±4%, respectively) and high Department of Cardiovascular Internal Medicine, First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, China (Zhang JY, Dong JZ, Li L, Zhao LS, Huang ZW, Wei JH and Liu RY) This work was supported by the Education Committee of Henan Province, China, and a grant from the Henan Science and Technology Committee. density lipoprotein cholesterol (HDL C) elevated (11%±3%) in the rabbits receiving 1% cholesterol diet supplemented with lovastatin, compared with those (including TC, LDL C, and HDL C) in the rabbits receiving 1% cholesterol diet and 1% cholesterol diet supplemented with L arginine, with alteration to the same degree. Endothelium dependent relaxations to acetylcholine were significantly impaired in aortae from the animals fed with a 1% cholesterol diet. By contrast, vessels from the hypercholesterolemic animals both receiving L arginine and lovastatin supplementation revealed significantly improved endothelium dependent relaxations. In addition, vessels from the hypercholesteroObjectives To investigate whether lovastatin improves endothelium dependent relaxation and decreases atherosclerosis in hypercholesterolemic animals, as compared with L arginine. Methods Forty male rabbits, randomized into four groups with ten in each group, were fed with one of the following diets: ① normal rabbit chow; ② 1% cholesterol diet; ③ 1% cholesterol diet supplemented with 2.25 g/kg L arginine soluble in the physiological salt solution (PPS) by gavage; ④ 1% cholesterol diet supplemented with 10 mg/kg lovastatin soluble in the PSS by gavage. The rabbits were fed with these diets for 10 weeks, and blood samples were collected from animals for biochemical studies. Then aortic rings were obtained, and changes in isometric tension were recorded. Intimal atherosclerotic areas of the aortae were subsequently measured by planimetry. Results Serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL C) levels were lower￣ ed (30%±6%, 39%±4%, respectively) and high Department of Cardiovascular Internal Medicine, First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, China (Zhang JY, Dong JZ, Li L, Zhao LS, Huang ZW, Wei JH and Liu RY) This work was supported by the Education Committee of Henan Province, China, and a grant from the Henan Science and Technology Committee. density lipoprotein cholesterol (HDL C) elevated (11%±3%) in the rabbits receiving 1% cholesterol diet supplemented with lovastatin, compared with those (including TC, LDL C, and HDL C) in the rabbits receiving 1% cholesterol diet and 1% cholesterol diet supplemented with L arginine, with alteration to the same degree. Endothelium dependent relaxations to acetylcholine were significantly impaired in aortae from the animals fed with a 1% cholesterol diet. By contrast, vessels from the hypercholesterolemic animals both receiving L arginine and lovastatin supplementation revealed significantly improved endothelium dependent relaxations. In addition, vessels from the hypercholestero

关 键 词：LOVASTATIN VASODILATION 

分 类 号：R540.2[医药卫生—心血管疾病]