Studies on the flow and distribution of leukocytes in mesentery microcirculation of rats  

作　　者：Jiang Y Liu AH Zhao KS 

机构地区：[1]Mil Med Univ 1st, Chinese PLA Lab Shock & Microcirculat, Guangzhou 510515, Peoples R China

出　　处：《World Journal of Gastroenterology》1999年第3期231-234,共4页世界胃肠病学杂志（英文版）

基　　金：Project supported by National Natural Science Foundation of China,No.39270852.

摘　　要：AIM To study the effect of leukocyteendothelium interaction (LEI) on the flow anddistribution of leukocytes in microcirculationunder physiological condition.METHODS A microcirculation image multipleparameter computer analysis system (MIMPCAS)was used to study the flow and distribution ofleukocytes in mesentery microcirculation of ratsIn vivo.RESULTS The difference of visible leukocyteflux (VLF) was as high as 131 times in thearterioles and venules with similar diameter andblood velocity. The visible leukocytes rolledalong the blood vessel wall as a" jerky"movement. The frequency distribution of thevisible leukocyte velocity (VLV) showed a "twopeak" Curve. The low peak value was at 10 pm/ s-- 15 pm/ s while the high peak fell between25 pm/ s-- 30 pm/ s. With the increase of diameterof venules, VLF increased while the VLVremained at the same level. With the increase ofRBC velocity, VLV trends to elevate and VLF tofal I down.CONCLUSION The results herein might providea basic theory for the study on the mechanism ofLEI under physiological condition and novelmethods for the prevention and treatment of highLEI in many pathologicalAIM:To study the effect of leukocyte-endothelium interaction (LEI) on the flow and distribution of leukocytes in microcirculation under physiological condition.METHODS:A microcirculation image multiple parameter computer analysis system (MIMPCAS) was used to study the flow and distribution of leukocytes in mesentery microcirculation of rats in vivo.RESULTS:The difference of visible leukocyte flux (VLF) was as high as 131 times in the arterioles and venules with similar diameter and blood velocity. The visible leukocytes rolled along the blood vessel wall as a jerky movement. The frequency distribution of the visible leukocyte velocity (VLV) showed a two peak curve. The low peak value was on 10&mgr;m/s-15&mgr;m/s while the high peak fell between 25&mgr;m/s-30&mgr;m/s. With the increase of diameter of venules, VLF increased while the VLV remained at the same level. With the increase of RBC velocity, VLV trends to elevate and VLF to fall down.CONCLUSION:The results herein might provide a basic theory for the study on the mechanism of LEI under physiological condition and novel methods for the prevention and treatment of high LEI in many pathological processes.

关 键 词：Studies on the flow and distribution of leukocytes in mesentery microcirculation of rats FLOW 

分 类 号：R363[医药卫生—病理学]